Zoetis Inc (ZTS) Q4 2020 Earnings Call Transcript

Zoetis Inc.  (NYSE: ZTS) Q4 2020 earnings call dated Feb. 16, 2021.

Corporate Participants:

Steve Frank — Vice President of Investor Relations

Kristin Peck — Chief Executive Officer

Glenn David — Executive Vice President and Chief Financial Officer

Analysts:

Jonathan Block — Stifel Financial Corp — Analyst

Michael Ryskin — Bank of America — Analyst

Louise Chen — Cantor Fitzgerald — Analyst

Erin Wright — Credit Suisse — Analyst

John Kreger — William Blair — Analyst

David Westenberg — Guggenheim Securities, LLC. — Analyst

Nathan Rich — Goldman Sachs — Analyst

Balaji Prasad — Barclays — Analyst

Chris Schott — J.P. Morgan — Analyst

David Risinger — Morgan Stanley — Analyst

Kathy Miner — Cowen and Company, LLC. — Analyst

Elliot Wilbur — Raymond James — Analyst

Sriker Nadipuram — UBS — Analyst

David Steinberg — Jefferies — Analyst

Gregg Gilbert — Truist Securities — Analyst

Presentation:

Operator

Welcome to the Fourth Quarter and Full Year 2020 Financial Results Conference Call and Webcast for Zoetis. Hosting the call today is Steve Frank, Vice President of Investor Relations for Zoetis. The presentation materials and additional financial tables are currently posted on the Investor Relations section of zoetis.com. The presentation slides can be managed by you, the viewer, and will not be forwarded automatically.

In addition, a replay of this call will be available approximately two hours after the conclusion of this call via dial-in information or on the Investor Relations section of zoetis.com. [Operator Instructions]. It is now my pleasure to turn the floor over to Steve Frank. Steve, you may begin.

Steve Frank — Vice President of Investor Relations

Thank you. Good morning, everyone, and welcome to the Zoetis fourth quarter and full year 2020 earnings call. I am joined today by Kristin Peck, our Chief Executive Officer; and Glenn David, our Chief Financial Officer. Before we begin, I’ll remind you that the slides presented on this call are available on the Investor Relations section of our website, and that our remarks today will include forward-looking statements and that actual results could differ materially from those projections.

For a list and description of certain factors that could cause results to differ, I refer you to the forward-looking statement in today’s press release and our SEC filings, including, but not limited to our annual report on Form 10-K and our reports on Form 10-Q. Our remarks today will also include references to certain financial measures, which were not prepared in accordance with Generally Accepted Accounting Principles or U.S. GAAP.

A reconciliation of these non-GAAP financial measures to the most directly comparable U.S. GAAP measures is included in the financial tables that accompany our earnings press release and in the Company’s 8-K filing dated today, February 16th, 2021. We also cite operational results, which exclude the impact of foreign exchange.

And with that, I will turn the call over to Kristin.

Kristin Peck — Chief Executive Officer

Thank you, Steve. Good morning, everyone. I hope you and your loved ones are all staying healthy. As we all know, we’re still experiencing hard times in many regions as COVID cases continue, and new variants of the virus emerge. But I hope you share my optimism that with progress in vaccinations and continued adherence to safety protocols, better days are ahead. The year 2020 will be remembered for COVID-19, but for Zoetis, it also reaffirms the resilience of our business, the essential nature of animal health and the agility and dedication of our colleagues in the face of industry and personal challenges.

Throughout the year, we successfully ensured colleague safety and maintained reliable supply for our customers. We kept driving innovation and strengthening our diverse portfolio of 13 blockbusters and more than 300 product lines across eight species and seven major product categories. We successfully launched our triple combination parasiticide, Simparica Trio. We also achieved approvals for the first ever long-acting monoclonal antibodies for osteoarthritis pain in dogs and cats.

With Librela’s authorization for dogs in the European Union and several other markets, and Solensia’s authorization for cats in Switzerland. We also continue to build on our vaccine portfolio in livestock with the approval of our CircoMax Myco swine vaccine in the European Union. And in poultry, we continued advancing our recombinant vector vaccines, with the approval of Poulvac Procerta HVT-IBD in the U.S.

Meanwhile, in diagnostics, we successfully launched VetScan Imagyst, a breakthrough platform using cloud based artificial intelligence for veterinary clinics. We were able to do all this while staying anchored to our purpose and advancing the five long-term priorities, that I set out at the beginning of the year, including sustainability, where we made important progress in our ESG programs and metric reporting. We look forward to sharing our long-term ESG goals in the coming weeks.

And finally, we delivered financial results for 2020 that were in line with the guidance we provided last February, before the impact of the global pandemic was known. For the full year, we generated 9% operational growth in revenue primarily based on new products in our companion animal business, the continued strength of our key dermatology portfolio and growth in China. And as part of our long-term value proposition, we once again grew revenues faster than the anticipated growth for 2020, and faster than the historical industry rates of 4% to 6%.

As part of our value proposition, we also delivered on growing our adjusted net income faster than revenue. For the full year, we delivered operational growth of 10% in adjusted net income while adapting our operations in the pandemic and continuing investments in our pipeline and new product launches. We generated strong fourth quarter results which Glenn will discuss in a minute, and these performance trends give us confidence in our growth drivers and strong momentum for 2021.

We expect to continue growing revenues faster than the market in 2021, driven by ongoing strength in petcare, continued expansion in markets outside the U.S., most notably China, and acceleration of our diagnostics portfolio penetration. We are guiding operational growth of 9% to 11% in revenue for full year 2021.

Growth expectations for the companion animal market are in the mid-single digits, and we expect Zoetis to grow significantly faster than that based on the continued uptake of Simparica Trio, the strength of our key dermatology portfolio and the launch of monoclonal antibodies in markets outside the U.S.

Positive pet care trends during the pandemic, based on increased adoptions and people spending more time with their pets, should continue driving market growth in the near-term. Data in the U.S., shows visits to veterinary clinics have rebounded and the average revenue per visit has continued to increase. Over the long term, we see these trends moderating as adoption rates normalize and people eventually return to the workplace.

The Specialty Care regimens and chronic care treatments that began in the pandemic should continue, and our innovative portfolio across dermatology, parasiticide, pain, vaccines and diagnostics have us well positioned for continued growth and capturing share as these shifts occur. In terms of livestock market, we expect low single digit market growth in 2021 as the impact from COVID-19 will still be felt, and a number of products experience loss of exclusivity.

We expect Zoetis to grow in line with the market even as we faced increased headwinds from generic competition for DRAXXIN, our leading anti-infective product.

We are confident we can leverage our lifecycle innovation strategies together with the overall diversity of our livestock portfolio, including swine product sales in China to help us address the loss of exclusivity for DRAXXIN and maintain livestock growth that will support our 2021 guidance. Longer term, we will continue to invest in livestock innovations and data driven animal agricultural solutions.

As we continue through 2021, we will be building on the progress against our five priorities. Driving innovative growth, enhancing customer experience, leading in digital and data analytics, cultivating a high performing organization and championing a healthier, more sustainable future.

Our investment plans and focus on growth for 2021 include, continuing the successful launch of Simparica Trio in the U.S. and other markets as well as the ongoing adoption of other new parasiticides, Revolution Plus and ProHeart 12, driving growth in dermatology through increased use of direct-to-consumer advertising and disease awareness campaigns in the U.S. and globally.

Our focus remains on growing this market and increasing customer loyalty through our innovative treatments, which we expect to help us top $1 billion in annual sales for the first time. As noted earlier, we will be investing in the launch of the first monoclonal antibodies for osteoarthritis pain in dogs and cats in Europe in the first half of 2021, and advancing the regulatory process in the U.S. and other markets. While we remain confident in the eventual U.S. approval of these products based on the safety and efficacy data we submitted, at this point, we believe it is unlikely we will receive approvals for Solensia or Librela in the U.S. in 2021. We continue to work through regulatory reviews and manufacturing inspections with the FDA and we will continue to keep you updated on this progress on future calls.

And finally, we’re continuing our development of digital and data solutions that will support more individualized animal care and more efficient and sustainable operations for producers. In conclusion, I’m incredibly proud of what our people accomplished in the face of such uncertainties during 2020, and it gives me great confidence in our continued success and full-year guidance for 2021.

As we navigate through recovery from the global pandemic, and capitalize on the growth opportunities we see ahead, my optimism comes from what drove us over the last year. The resilience and essential nature of animal health industry, the diversity, innovation and market leadership of our portfolio, and the agility and passion of our colleagues to face any challenge.

Now, let me hand it off to Glenn who will speak more about our fourth quarter results and guidance for the full year 2021.

Glenn David — Executive Vice President and Chief Financial Officer

Thank you, Kristin, and good morning everyone. We had another exceptional year with revenue of $6.7 billion and adjusted net income of $1.8 billion, both exceeding the high end of our November full-year guidance range. Full year revenue grew 9% operationally and 7% on a reported basis with adjusted net income increasing 10% operationally and 5% on a reported basis.

Going deeper into the numbers, price contributed 2% to full year operational revenue growth with volume contributing 7%. Volume growth consisted of 3% from new products, 3% from key dermatology products and 1% from acquisitions, with other in-line products flat for the year. We again saw broad-based revenue growth with the U.S. growing 11% and International growing 7% operationally. The innovation we brought to the market and the diversity of our portfolio was key to our strong performance, as companion animal grew 17% while livestock was flat on a year-over-year basis.

Performance in companion animal was led by our parasiticide portfolio, bolstered by the launch of Simparica Trio which generated revenue of $170 million. This added approximately $150 million of incremental revenue and exceeded our expectations set prior to the pandemic. Sales of Simparica also grew double-digits for the year with operational revenue growth of 16%. Our key dermatology portfolio demonstrated continued strength in 2020 growing 23% operationally, generating revenue of $925 million and increasing more than $170 million versus prior year. The COVID-19 pandemic created a difficult market environment for livestock. However, we are encouraged by the resiliency displayed in 2020.

We remain optimistic that global livestock will return to modest growth in 2021 as the recovery from African swine fever in China continues and consumption patterns normalize. Operational growth and adjusted net income of 10% were driven mainly by strong revenue growth and operating margin expansion. Now, moving on to our Q4 financial results where we posted another strong quarter with revenue of $1.8 billion representing an increase of 9% operationally and 8% reported.

Adjusted net income of $438 million is an increase of 3% operationally and flat on a reported basis. Operational revenue grew 9% with 2% from price and 7% from volume. Volume growth of 7% consisted of 4% from new products, 3% from key dermatology products, 1% from acquisitions and a decline of 1% from other in-line products. Companion animal products led the way in terms of species growth, growing 25% operationally, while livestock declined 5% operationally in the quarter. Companion animal parasiticides grew 52% in the quarter, gaining market share in the U.S. of more than 7% within the flea, tick and heartworm segment, versus the same period in the prior year.

This includes the continued adoption of Simparica Trio which generated sales of $60 million in Q4. Our key dermatology products, Apoquel and Cytopoint again had significant global growth in the quarter with $257 million of revenue, representing 27% operational growth versus an extremely difficult comparative period in which key derm grew 29% for the fourth quarter of last year.

Our diagnostics portfolio again made positive contributions to revenue with reference lab expansion and double-digit growth in consumables and instrument revenue. The recovery in wellness visits continued to be a catalyst for growth following the slowdown from social distancing restrictions earlier in the year. As we noted on our previous earnings call, the early fall cattle run pulled a portion of fourth quarter sales into the third quarter, leading to a weaker quarter in cattle than we would typically expect. This was the primary driver of the 5% operational decline in livestock for the fourth quarter.

For the remainder of the livestock portfolio, swine posted a second consecutive quarter of growth with the herd rebuild continuing key accounts, as the market recovers from African swine fever in China. Our aquaculture business grew high single digits in the quarter, and along with swine partially offset the decline in cattle and poultry. Now moving on to revenue growth by segment for the quarter, U.S. revenue grew 11% with companion animal products growing 30% and livestock sales declining by 15%.

For companion animal, the positive trends at the vet clinic continued in Q4 with patient visits up 2% and revenue per visit increasing by 13%. Companion animal growth in the quarter were driven by sales of our Simparica franchise as well as key dermatology products. We maintained an increased investment in direct-to-consumer advertising in both therapeutic areas and continue to see a good return on that investment.

Simparica Trio performed well again in the quarter with sales of $56 million. We remain extremely encouraged for the future growth of our product and the growth of the overall market segment as a material portion of Trio sales came from new patients to the category. Key dermatology sales were $176 million for the quarter, growing 32% with significant growth for Apoquel and Cytopoint. Our investments to support the franchise have been instrumental in driving more patients into the clinics.

Companion animal diagnostic sales increased 22% in the quarter as a result of reference lab expansion and growth in point-of-care instruments and consumables. U.S. livestock declined 15% in the quarter driven primarily by cattle, which had a portion of Q4 sales pulled into the third quarter as a result of the earlier movement from pasture to feedlot. The remaining species declined as well with COVID-19 and pricing pressure negatively impacting our swine business.

Poultry declines are largely attributed to product rotation and less producer profitability, leading to reduced usage of our premium products. To summarize U.S performance, innovation and return on investment once again drove exceptionally strong growth in companion animal. While livestock was down in the quarter, the results were in line with our expectations. Revenue in our International segment grew 7% operationally in the quarter.

Companion animal revenue grew 17% operationally and livestock revenue grew 2% operationally. Increased sales of companion animal products resulted from growth in our parasiticide portfolio, vaccines and key dermatology products. Parasiticide growth in the quarter was again driven by the Simparica franchise with further adoption of Simparica Trio. In Q4, we observed a series of favorable market trends, such as increased pet ownership and medicalization rates in Asia.

Overall, companion animal grew in every major market except Italy and the U.K., which had arguably the strictest lockdown protocols. Companion animal diagnostics grew 16% in the quarter, led by an increase in point-of-care consumable usage. Swine revenue grew 14% operationally, posting a third consecutive quarter of double-digit growth. Swine sales in China grew in excess of 100% for the second straight quarter. Key accounts expanded their use of vaccines and other products as they continue to rebuild herds from smaller farms to large-scale operations. China total products grew 45% operationally in the quarter and 34% operationally for 2020.

Brazil was also a significant contributor to international growth in the quarter, growing 18% operationally. For the fourth quarter and full year 2020, Brazil delivered double-digit growth in all species except poultry which modestly declined. Overall, our International segment delivered strong results despite the challenges presented by COVID-19. Our diversity across products and geographies enabled our international segment to again be a significant driver of growth.

Now moving on to the rest of the P&L for the quarter. Adjusted gross margin of 67.7%, fell 80 basis points on a reported basis compared to the prior year resulting from other manufacturing costs, inventory charges, recent acquisitions and elevated freight expense. This was partially offset by favorable product mix and price increases. Adjusted operating expenses increased 10% operationally, resulting from increased advertising and promotion expense for Simparica Trio and Apoquel, partially offset by T&E savings. Return on investment from our DTC campaigns has been very favorable and we remain — and will remain an important investment to support future growth of the business.

The adjusted effective tax rate for the quarter was 13.5%, a decrease of 70 basis points, driven by the impact of net discrete tax benefits, partially offset by the jurisdictional mix of earnings. And finally, adjusted net income and adjusted diluted EPS for the quarter grew 3% operationally. In December, we announced 25% annual dividend increase, continuing our commitment to grow our dividend at or faster than the growth in adjusted net income. In addition, we resumed our share repurchase program in January with $1.4 billion of remaining capacity under the current authorization.

Now moving on to guidance for 2021, please note that guidance reflects foreign exchange rates as of late January. For 2021, we are projecting revenue between $7.400 billion and $7.550 billion representing 9% to 11% operational growth. We are expecting foreign exchange favorability in 2021 of approximately 200 basis points. We expect companion animal to be the primary driver of growth in 2021 with the continued strength of our diverse parasiticide portfolio which includes full year Simparica Trio sales.

We believe market dynamics for companion animal will remain strong in 2021 allowing for further expansion of our key dermatology products as well as our diagnostics offerings, which we anticipate will grow faster than the overall animal health market. While we expect the pace of certain trends that accelerate in 2020 to moderate, such as increased spend per visit, our view is that 2020 has a status [Phonetic] of the higher base for future growth. We anticipate livestock will return to global growth in 2021, primarily driven by more normalized food consumption patterns.

Geographically, we expect total Company sales growth to be relatively balanced between our U.S. and International segments. However, we do expect continued and meaningful growth in China and other emerging markets. I’d like to touch upon the key assumptions that underpin our expectations for revenue growth. Beginning with dermatology, our guidance does not assume a meaningful competitive entrant in 2021 and with continued investment behind the franchise, we believe revenue will exceed $1 billion for the full year. We also do not assume a triple combination product will launch in the U.S. in 2021 to compete against Simparica Trio.

We’re extremely excited about our monoclonal antibodies for pain with both Librela and Solensia having long term blockbuster potential. However, as Kristin mentioned, while both products will launch in the first half of 2021 in the EU and other international markets, we do not currently expect either product to receive approval in the U.S. this year.

For the remainder of the P&L, adjusted cost of sales as a percentage of revenue is expected to be approximately 30% which is relatively consistent with our cost of sales in 2020. Adjusted SG&A expenses for the year are expected to be between $1.775 billion and $1.85 billion with the increase from 2020 focused on supporting primary drivers of revenue growth, including recent and future product launches, key brands and recent acquisitions and reference lab expansion in diagnostics.

Adjusted R&D expense for 2021 is expected to be between $500 million and $520 million as we remain committed to investing in pipeline opportunities for new therapies and lifecycle innovation. Adjusted interest and other income deductions is expected to be approximately $260 million with the increase over 2020 driven by increased interest expense as well as lower interest income.

Our adjusted effective tax rate for 2021 is expected to be approximately 20%. The increase in 2021 is primarily related to the impact of favorable non-recurring discrete items that occurred in 2020. Adjusted net income is expected to be in a range of $2.08 billion to $2.13 billion, representing operational growth of 9% to 12%. Our guidance reflects our value proposition of growing revenue in line with or faster than the market and growing adjusted net income faster than revenue, during a year when we’ll be making meaningful investments to support future growth.

Consistent with 2020, we are anticipating elevated capital expenditures in 2021 to support investments in manufacturing, focused on internal sourcing of API, capacity increases and facilities to support pipeline opportunities. We’re also investing in information technology to support our recent acquisitions as well as digital capabilities and data analytics.

Finally, we expect adjusted diluted EPS to be in the range of $4.36 to $4.46, and reported diluted EPS to be in the range of $4.02 to $4.14. While guidance represents full year expectations, we do anticipate growth will be more heavily weighted towards the first half of the year. This is largely due to full year Simparica Trio sales and a favorable comparison versus Q2 2020 as a result of COVID-19.

To summarize, 2020 was another exceptional year in which we delivered 9% operational revenue growth and 10% operational growth in adjusted net income. In the year that presented a unique set of challenges. Our guidance for 2021 highlights our ability to grow revenue organically above the market and grow adjusted net income faster than revenue, even during times of elevated investment.

Before turning it over to Q&A, I’d like to express how proud I am of our colleagues and all we’ve accomplished amidst an unprecedented set of circumstances. While there is no assurance that the new year will be without similar challenges faced in 2020, we cannot be more excited about the opportunity to again deliver on our long-term shareholder value proposition.

Now, I’ll hand things over to the operator to open the line for your questions. Operator?

Questions and Answers:

Operator

Certainly. [Operator Instructions]. And we will take our first question from Jon Block with Stifel. Please go ahead.

Jonathan Block — Stifel Financial Corp — Analyst

Thanks guys, good morning. Congrats on just a great 2020. I’ll ask both upfront [Phonetic]. For the quarter, 4Q20 gross margins were a bit below despite be it companion animal growth, and next year, it seems like you’re guiding to flattish, call it gross margins again, despite what seems like positive mix shift.

So, Glenn, can you talk about that a bit? Why are we not seeing a bit more of gross margin considering the companion animal performance? And is expanding gross margin still a part of the long-term story? And then I’ll stick with sort of guidance, just really big numbers on 2021 guidance out of the gate, you talked of livestock versus companion, can you talk to the components of companion animal a little bit more? I don’t know if I specifically heard Trio number, so is it safe to assume Trio $400 million plus in any other components you’d call out?

Thanks guys.

Glenn David — Executive Vice President and Chief Financial Officer

Sure, Jon. So firstly, if you look at the gross margin expectation for 2021, it is relatively flat versus 2020. As you mentioned, the mix with companion animal will be beneficial as we move into 2021. Some of the offsets for that, though some of the investments that we’re making in other areas such as reference labs, which come at a lower margin, particularly in the early stage of their life cycle as we’re building those labs, at those labs, the margins will be a little lower until they reach their full operating scale.

So that’s some of the offset. So there were some positives in terms of the companion animal mix, some offsets there with some of the longer terms we’re investing in other — making in other areas. In terms of the drivers of companion animal growth, so obviously, we do expect Trio to be a significant driver of growth for 2021.

We’re not putting a specific number on Trio, but we would expect a contribution from growth in 2021 to be at least as big as what we achieved in 2020. So that will obviously be one of the drivers. Also, continued growth in our dermatology portfolio. We saw very strong performance in 2020 with 23% growth in that portfolio operationally for the year. We do expect that portfolio will exceed $1 billion as we move into 2021.

Also in companion animal diagnostics, we expect very rapid growth in diagnostics as well. In the fourth quarter, we saw a 20% growth and we expect that will help carry us forward with the strong momentum that we had in the quarter into 2021 as well as strong performance that we’re seeing in many of our emerging markets such as China and Brazil.

So those are some of the factors that are driving the strong companion animal growth.

Operator

Our next question comes from Michael Ryskin with Bank of America. Please go ahead.

Michael Ryskin — Bank of America — Analyst

Hey, thanks guys. If I may ask a quick two parter. First one is going to be on livestock markets and just specifically on DRAXXIN, are you starting to see some competition? I know the patents have just rolled off, but any early comments you can tell us in terms of pricing from competing launches and sort of expected — up to date expectations of market share, but also what steps you’re taking and how meaningful the headwind do you expect in 2021?

And then broader on the livestock, we’ve heard a lot about input costs going higher on corn [Phonetic], things like that potentially pressuring producers in some markets, such as poultry and swine. How does that factor into your outlook for low-single digit growth? And then second question would be just a little bit more on the companion animal expectations for 2021. Obviously you’re growing well above the market, but any thoughts on sort of in-line portfolio, and you commented on Trio, you commented on strong term strength and where you’re seeing Librela. But just can you sort of comment on Revolution Plus and on the rest of the portfolio there?

Kristin Peck — Chief Executive Officer

Thanks, Mike. So starting on DRAXXIN, we are expecting a number of competitors to enter in the U.S. market. Again, the LOE is this month, so it hasn’t happened yet. I would say more probably entrants than we expected a few months ago, but we don’t think that will last obviously. I think the market will shake out obviously to a few.

As we’ve said previously, typically, we expect about — to lose about 20% to 40% share over several years. In the case of DRAXXIN, given the large number of competitors, we do expect that to be faster, but we don’t really expect it to be overall different. And really partly what drives that I think is, we do believe that a lower price on DRAXXIN will expand the market for macrolides overall. And therefore the market itself will grow.

We also think we’re positioned well from a broad portfolio, strong technical. We do expect that — the price to come down in the 20% to 40%, but that is an expectation. But as we’ve said, this is all baked in right now to our guidance. So the expectations around where DRAXXIN is going to be, is there. And if you look at broader livestock, you referenced some of the input costs. If you heard in some of our opening remarks, we are expecting low single-digit growth. So, a return to growth in livestock overall.

And you know, some of that will be led in the U.S. in some sort of species, a lot of that will be led outside the U.S. As a reminder, about 60% of our livestock business is outside of the U.S. and we’re seeing incredible growth right now in China and some other markets, Brazil, etc.

So overall, we do think some of the input cost in the U.S. will be a pressure, but we have — you know, given the diversity of our portfolio, looking at some large markets, our second largest market is China, our third largest market is Brazil. We do see strength in livestock there. So we overall do believe livestock will return to low single-digit growth in 2021. And we continue to believe it will return to normal growth in the mid-single digit range of 4% to 6% over the medium term.

So Glenn, I’m not sure if you want to take the incremental question on the broad companion animal trends in ’21.

Glenn David — Executive Vice President and Chief Financial Officer

Yeah. So the trends for companion animal remained very strong, and it’s really driven by the breadth of our portfolio. So we talk a lot about the growth that we expect to see from Trio, from our derm portfolio, from a diagnostics portfolio. Also in 2021, we’ll have the launch of our monoclonal antibodies for pain in Europe as well as some other markets will also be a key contributor to growth.

But then there are other products that round out to portfolio, products such as ProHeart 12, products such as Revolution Plus. Also, the growth that we’re seeing in markets like China where companion animal is growing very rapidly in markets like Brazil. So there are really many areas of growth that we see. And that’s driven by the fact that we do have the broadest portfolio in companion animal we’re able to leverage that with our customers.

Operator

And our next question comes from Louise Chen with Cantor Fitzgerald. Please go ahead.

Louise Chen — Cantor Fitzgerald — Analyst

Hi, thanks for taking my question. So what are the macro factors that you see for Zoetis in 2021, as it pertains to livestock, feed prices, whether any other headwinds or tailwinds that you see out there? Thank you.

Kristin Peck — Chief Executive Officer

Sure, Louise. Good to hear from you. As you look at livestock overall, we’re seeing some of the macro trends and sort of a recovery in China, around ASF is driving a significant portion of the growth from a swine perspective. China still going to be importing a decent amount probably less than in 2020 from other markets around the world, sort of maintaining that. We’re also hopeful that you will see an increase in dine out which will send signal to the industry to expand herds.

So, I mean, 2020 was obviously hit with many different factors. But we do see both an increase in demand and in markets where our technology to really leverage some of the emerging markets where we were seeing significant uptick there. There will remain challenges in some of the U.S. producers, obviously for some of the input costs, etc. But we do believe you’ll see more of a return to normalcy as we move into 2021, and that’s why we are guiding at sort of the low-single digit, but we do believe in the medium term, we’ll be back to sort of a mid-single digit overall.

Operator

And our next question comes from Erin Wright with Credit Suisse. Please go ahead.

Erin Wright — Credit Suisse — Analyst

Hi, thanks. I’m curious how the multiformulation approach towards parasiticide is — [Technical Issues] and [Technical Issues] historically on [Technical Issues] cannibalization of legacy products, they’re playing out in line with your expectations?

And my second question is on the new pain [Phonetic] mAb. How should we think about the contributions from them this year in Europe, or other countries to be meaningful at all and how should we think about the dynamics that are impacting approval in the U.S., do you still anticipate or are you still confident that these will be blockbuster products for you with the launch in the U.S. in 2022?

Kristin Peck — Chief Executive Officer

Thanks, Erin. I heard the second question on mAb, which I can answer, you were breaking up and digitizing on the first question, I think we more or less have it, so let us give a shot and you can comment if we missed some of that — some of what we heard. So starting on your second question on the mAb, we were very excited to now have Librela approved and launching in the first half of this year in the EU, Brazil, Canada, and Switzerland. And Solensia, we continue to expect approval in the EU in the first half this year and to be launching sort of mid-year. We already do have approval on Solensia in Switzerland.

And we remain confident in the eventual approval based on the safety and efficacy data we submitted in the U.S., but as you saw in our remarks and in our release, the approval timeline has moved out a bit. We believe this has to do with the fact that this is the first monoclonal antibody approved by the FDA in animal health. Our previous one, Cytopoint was actually USDA. It’s making it a little harder for us honestly to predict some of the regulatory process.

We’re continuing to work through the regulatory process and manufacturing infection, and we’ll continue to keep you updated. We don’t think that changes the overall peak sales of this product at all. But it is a slightly different process. And I guess Glenn might have understood a little bit better. We’ll try to your first question. Just let us know if we missed it.

Glenn David — Executive Vice President and Chief Financial Officer

Yeah. So Erin, I think your question was around how we’re performing with the breadth of our portfolio from parasiticide with our customers. And I think that’s going very well in the veterinary clinics. We’re really able to offer our customers a variety of options based on how they want to best treat the animals. And I think that shows in the performance that we saw on the Simparica franchise in 2020. Not only did we exceed our goals for Trio with $170 million in sales in the year, but we also saw significant growth in Simparica which really exceeded our expectations.

So we grew operationally 16% with Simparica, so what we saw was that the advertising and driving patients into the clinic for Simparica Trio actually benefited the overall portfolio. We also saw a very positive growth in ProHeart 12 as well. So we think the breadth of the portfolio in the parasiticide was really a benefit and our field colleagues were really able to execute very well with that portfolio.

Kristin Peck — Chief Executive Officer

Was that your question? Did we get it off? Okay. All right. You can come back in the queue if we missed you. Sorry about that, you were a little bit digital.

Operator

Okay. We will take our next question from John Kreger with William Blair. Please go ahead.

John Kreger — William Blair — Analyst

Hi, thanks very much. Just maybe a quick follow-up on the Librela and Solensia timeline in the U.S. Do you have a sense for how far pushed back the approval timing might be? And do you think you need to collect additional clinical data?

Kristin Peck — Chief Executive Officer

Yeah. We don’t have a great sense right now. We’re still working through the regulatory and manufacturing process. We also — the FDAs did require inspections of facilities that are outside the U.S. So the exact timing of when they’re going to be able to do that is a little bit uncertain. So I don’t have a great sense. If we did, we would have obviously given more specific guidance. We do not expect it to be in 2021 which is what we’re being clear on now.

And as soon as we know more, we’ll be happy to update on future calls going forward. But unfortunately, I don’t have great — again, we remain very confident that will eventually be approved. But we need to go through a new process with the regulator has — in animal health under CVM approved monoclonal antibodies previously.

So it’s a little bit different for us. So this is the best we know at this point.

John Kreger — William Blair — Analyst

Great. Thank you. And then a second question. Can you maybe just sort of frame the diagnostics plan for ’21. It seems like results are starting to accelerate there. Are any of the investments being focused in the livestock, or should we really think about your efforts right now being concentrated with companion animal?

Kristin Peck — Chief Executive Officer

Sure. For 2021, our focus remains on companion animal. We’re very pleased with our progress on placements, which is a really good leading indicator of usage. As you saw, we had double-digit consumable growth as well, which we’re quite pleased with. Well, if we look at new products we’ve added, the Imagyst platform, we’re excited with its first indication obviously in fecal, that’s the AI powered one. We’re looking for additional indications there.

So the last piece there would also be reference labs. So we’re continuing to expand our U.S. reference lab probably adding about three to five more labs this year. So we believe diagnostics is a core part of our portfolio. It’s a market that grows at 10% plus. We’re really pleased that we’re starting to see some strong momentum across the different parts of it. So both reference lab as well as placements, as well as consumables.

So we remain very committed to the space and are pleased with our progress over them.

Operator

And our next question comes from David Westenberg with Guggenheim Securities. Please go ahead.

David Westenberg — Guggenheim Securities, LLC. — Analyst

Hi. Thank you for taking the questions and congrats on a great year. Can you give us a little bit of flavor on where Trio is taking share from? I think you mentioned there is some new to the category, but I’m just kind of get — trying to get a flavor, is it, you know, legacy, just legacy flea and tick? What component is heartworm? And basically what I’m trying to do is get a good sense of how big this can grow in terms of both the heartworm market and the flea and tick market?

And then just a second related question on Trio. Is there any synergies, particularly on a sales synergy from the direct-to-consumer marketing campaigns that might be of benefit, maybe derm or maybe there is cost synergies. So thank you very much.

Kristin Peck — Chief Executive Officer

Sure. So starting on the Trio. We did see an increase in share in Q4 of 7%. So we are taking share. You know, there’s a number of places that’s coming from. If you think about it, the first is new puppies where I think we’re doing quite well with new I think, puppies. Also new people to the category overall, I would say people who maybe previously, have gotten products over the counter are moving in and we are taking share from some of the other established competitors in the space.

So I think we’re seeing strong growth overall, I would say there and pleased at our share. If you look at the potential for the products, the two competitors both NexGard and Bravecto are each $600 million product to date. So we continue to believe there is significant growth. We remain under indexed to be honest with you in terms of the size. So we continue to see this as a significant part of our overall growth.

From a sense of is — are there synergies with derm? Not really is what I would say, except for on the cost side, obviously we can get better buying power when you replace DTC at by leveraging the spend across both. But beyond that, we don’t see strong synergies honestly between the DTC on one affecting the other unless our clinic has to carry both and things like that. But we think maybe the only synergy there is that, and our buying power by leveraging the combined DTC spend.

Operator

And we can go to our next question from Nathan Rich with Goldman Sachs. Please go ahead.

Nathan Rich — Goldman Sachs — Analyst

Hi, good morning, thanks for the questions. Kristin, maybe to start, what do you think the launch curve looks like for products like Librela and Solensia? Obviously, a new way for vets to treat osteoarthritis and chronic pain. I guess, kind of what are your initial kind of impressions on sort of the level of demand that’s out there from vets for this type of treatment? And how will Librela be priced relative to existing treatments on the market? I know it can be kind of up to $100 a month here in the U.S. I’m sure it varies a lot by market, but just any comment on pricing would be helpful.

Kristin Peck — Chief Executive Officer

Sure. I think the lifecycle for Librela and Solensia in the curve will be slightly different. Librela is entering a market that’s $400 million today. So it’s an established market. So I think the ability for — you know, people are already bringing their dogs in for OA pain. So I think we have the opportunity with Librela to expand the number of patients, given the safety and efficacy profile and the compliance benefits of the product.

I think we can also increase days on therapy. So our — which also helps us grow the market. And then obviously price to your point. So it is priced at a premium to many of the products on the market today. It is not — obviously, we don’t have a price in U.S. since we don’t have an approval yet in the U.S.

I think, Solensia is going to be a little bit different, I think the curve is going to take a little longer. And that has to do with the fact that there really isn’t a market today in most parts of the world. If you had a cat with OA, there really was no treatment. So cat owners are kind of in a condition to not bring their cats in. We started focusing about a year ago, to try to build that market, make pet owners aware what OA pain looks like in cat, and get encourage them to start bringing their cats to the vets and then getting vets to treat that.

We think it’s a significant market, but you have to first medicalize some of these conditions and treat it. It’s significant, there’s 50 million cats in the U.S. today and really only — about 40% of them have OA, but only 18% of them are really identified by vet. So, we think both are significant markets that we can grow the market. Solensia is more about creating a market. And I think you can look at our success in doing that with dermatology, with Apoquel and Cytopoint.

So we are investing early as Glenn has been talking about in some of the guidance over the last year and for 2021 in building those markets. But I would assume the curve for Librela will be much faster than the curve for Solensia, as we’re building a market.

Operator

And our next question comes from Balaji Prasad with Barclays. Please go ahead.

Balaji Prasad — Barclays — Analyst

Hi, good morning and congratulations on the results. A couple of questions from me. Firstly, since livestock recovery this year seems to be so contingent on China and there are news of unregulatory or illegal vaccines being used and the recurrence of ACF. So I want to understand what you’re seeing on the ground and how should we wrap our heads around the reherding cycle in 2021?

Second on the operating margins, considering that you will not have the dilutive impact of diagnostics that you saw in 2020, should we be looking for better operating margins considering that revenue mix is better, livestock should be in a recovery and if so, what are the offsets to these? Thanks.

Glenn David — Executive Vice President and Chief Financial Officer

Sure. So when you look at overall livestock and particularly in China, so we’ve seen very positive performance in livestock in China this year. So from a livestock perspective, we grew 45% in China this year, and we expect continued strong performance in China in 2021 as we continue to see the herd rebuild recovery from African swine fever and where we’re seeing that recovery is particularly in our larger accounts. And the larger accounts use more of the multinational products in our premium products.

So we’ve seen a really rapid acceleration of our growth. For example, in the second half of the year in swine, in particular in 2020, we grew over 100% in swine in China and we expect very positive momentum moving into 2021, and a very significant growth from China in 2021. In terms of the operating margins, there are a couple of things to look at as we move into 2021. A, number of areas of investments that we have in our SG&A really continuing to support the growth of Trio as well as the monoclonal antibodies for pain as well as dermatology. We’ve increased our DTC investment in 2020, particularly around Trio and derm and we plan on continuing that in 2021 as we saw a very positive return on investment there.

Obviously, we’ll continue to invest in R&D. And that will be an area of continued investment as we’ve seen very positive return on that investment as well. The other thing to consider when you look at the overall guidance which with revenue growing 9% to 11%, and income growing 9% to 12%, one of the reasons that income isn’t growing more rapidly is the change in assumption and tax rate between 2020 and 2021.

In 2020, our rate was 18.3%. Our guidance for 2021 is approximately 20%. If you neutralize for the impact of the tax rate, our adjusted net income would actually be growing 2% faster, so a more 11% to 14%. So we are seeing margin expansion, but the impact of the tax rate is diluting that to some degree.

Operator

And we’ll go next to Chris Schott with J.P. Morgan. Please go ahead.

Chris Schott — J.P. Morgan — Analyst

Great. Thanks so much. Can you talk of first maybe a bit about innovation on the livestock side? It seems like the market between COVID and similar dynamics has been kind of a bit lackluster in terms of growth for last few years. So what does it take to get back to mid-single-digit growth on the livestock side? And what are some of the bigger innovation trends we should be watching there?

And my second question was just following up on the topic of margins. As we start looking up to 2022 and beyond, should we be thinking about a sustained window of higher expense growth as you get many of these new launches off the ground, or is lot of that groundwork already been, I guess, invested as we go into ’20 and ’21? I’m trying to get a sense of how we should think about longer-term margin expansion dynamics assuming we continue this very healthy top line set up of things to be playing out. Thanks so much.

Kristin Peck — Chief Executive Officer

Thanks, Chris. We have been talking about the fact that to really get to the mid-single digits in a sustainable way, you’re going to need innovation. I think there’s a few spaces that we’re already starting to see that and some of that will be coming. The first is around the vector vaccine space which we’ve been talking about. In 2020, we launched our first one in the U.S. for new cattle, in 2021, we launched one for IBD. We’re looking for more launches there. This is a significant market, it’s about $300 million market growing double-digit.

So we do see vector technology in poultry which is one of the faster growing species being an area of innovation and growth for us. We also think more broadly that immunotherapy, they’re going to be really important for two reasons. One, they’re alternative to antibiotics, and secondly healthier animals are more productive. So it also increases productivity for producers. So I think immunotherapy, which we’ve been working on for a while and have a partnership with Colorado State to develop will be important.

The other factor that I think is really important to focus on is precision livestock farming, which we also think has great potential. We’re leaders right now in the genetic space there, in genetic testing. We also purchased PLA as you know, we’re looking at really back-to-back [Phonetic] individual animal care and herd monitoring. And I think that’s probably the next big way, that’s probably more of a medium-term growth driver. But I think there is a number of spaces where you’re going to see innovation at the livestock spot. So across vectors, immunotherapies and precision livestock farming.

I’ll let Glenn take the second question on long-term margin expansion.

Glenn David — Executive Vice President and Chief Financial Officer

Yeah, so in terms of the long-term margin expansion, I think there are a couple of factors to consider. So for 2021, we mentioned that the gross margin is relatively flat and talked about some of the drivers of that with some of the investments we’re making in reference labs. Also the impact of the DRAXXIN LOE this year on gross margin. So as we move into 2022 and beyond, some of those impacts will be a little less and we would expect to see continued expansion in gross margin.

In terms of the overall operating expenses, beyond 2021, obviously there will be one year where T&E normalizes when things get back to normal from COVID. But beyond that impact, we would expect that we would continue to be able to grow our expenses at a pace below that of revenue.

So we’ll probably continue to grow R&D in line with revenue, that may vary any given year based on the opportunities, but SG&A based on the infrastructure that we have globally established, we should be able to grow that somewhere between inflation and revenue. So we would expect to continue to see expansion there on an overall operating margin perspective.

Operator

Our next question will come from David Risinger with Morgan Stanley. Please go ahead.

David Risinger — Morgan Stanley — Analyst

Yes, thanks very much and let me add my congrats on another phenomenal year as well. So I have two questions. First, with respect to the monoclonal antibody approval delays, so it’s for both cats and dogs, but it wasn’t quite clear to me whether the FDA wants more clinical data or whether there are manufacturing issues because of manufacturing questions because I think Kristin you had mentioned manufacturing. So if you could just clarify on both of them what the FDA issues are whether they are clinical or manufacturing?

And then second, Zoetis’ R&D has obviously been amazingly differentiated from competitors. Competitors struggle to bring blockbuster companion animal products to market, even including follow-ons to Zoetis’ top growth drivers over several years. And so considering that, can you just help us understand the unique aspects of Zoetis’ R&D and its ability to maintain separation from the competition? Thank you.

Kristin Peck — Chief Executive Officer

Sure. Thanks, Dave. With regards to the monoclonal antibodies, Librela and Solensia, it really is just working through the regulatory process and the questions that they are asking and they’re requiring inspection of sites. So at this point we have not been asked for any clinical data, but we’re still in the regulatory process is what I would say. It is the first time doing this with the FDA, so it’s just honestly a new process for both and understandably it’s the first time they’re looking at some of these types of products, so they have a number of questions.

So it really is just going through the regulatory review process and trying to manage new manufacturing inspections, which I do know that probably COVID is definitely affecting that a little bit, but we’re just working through that. So at this point we have not been asked for any additional clinical data and we don’t think there’s any manufacturing issues at this point, we’re just still working through the review process and what their expectations are.

With regard to Zoetis R&D, what I would say is I think it’s a partnership between R&D, manufacturing and our commercial organization. It’s taking those insight the commercial has of customer needs and partnering early on with R&D to develop products. I think the other thing we’ve done really well is partner with manufacturing to be able to scale those products, and be able to bring them to market.

We manufacture our own monoclonal antibodies as you know, we’ve got very strong manufacturing capabilities, which is I think important for launching many of the products and scaling up at the level. We certainly learned the hard way early on in our journey about investing in that partnership when we got some of the challenges we had at supplying Apoquel.

So, I think from an R&D perspective, obviously, I think we have great scientists, but I think it’s the rigorous through [Phonetic] process and partnership they have with our commercial and our manufacturing colleagues and our willingness to invest in disruptive technologies and take those risks that we’ve been doing — we’ve been managing over the last eight years.

Anything you’d add there, Glenn?

Glenn David — Executive Vice President and Chief Financial Officer

No, I think it’s exactly what you said Kristin, we talked about the capabilities between commercial manufacturing and R&D and I think that works extremely well, like Kristin said identifying what the key needs are in the marketplace early on coming up with solutions and making sure that the products that we’re able to manufacture and we’ve been very successful in doing that.

Operator

The next question will come from Kathy Miner with Cowen & Company. Please go ahead.

Kathy Miner — Cowen and Company, LLC. — Analyst

Good morning. Thank you. First question I have is relates again to the monoclonal. Can you just clarify when you talked about plant — site inspections being needed, is it correct then both either one or both of the monoclonal are manufactured outside of the U.S.? Second question also on the products is the intention to launch both the cat and dog ones at the same time, is there an advantage to do in one or the other, and we can speak just about the EU markets where you have approval?

And the second question on the derm products, you’ve targeted $1 billion in sales for this year. Can you talk about some of the drivers behind that? Is it outside of the U.S., is it more pets etc.? Thank you.

Kristin Peck — Chief Executive Officer

Sure. So first of all, Kathy, great to hear from you. Secondly on the mAb, they are both — the manufacturing facilities are different for them, but they are outside the U.S. and prior approval inspections, regulators handle them differently but, they are going to be required probably for both of these products and they are both different, but they are both outside of the U.S.

And I think your second question was around the derm sales growth U.S. or ex-U.S., it’s both. We still believe we’re under-penetrated by U.S. with the same number of dogs in the U.S. and outside U.S., yet, two-thirds of our sales in derm remain in the U.S. So we do think there is a significant opportunity. It has been harder to get — scale outside the U.S., historically, mostly because we’ve not been able to do direct-to-consumer advertising this brand specific.

One of the investments we are going to make for the first time is doing just overall disease awareness direct-to-consumer advertising in 2021. So we cannot be specific with brands, but in derm, we really are the only product.

So hopefully if you raise awareness around a disease and that our treatments, you can encourage people to speak to their vet and get the best care. So that I think is one of the reasons why International we are hoping will start to grow faster. But I have to give our U.S. team tremendous credit. They continue to grow the market. The investment in direct-to-consumer advertising, raising awareness of our products are bringing more pets in and getting more pets treated. And in the U.S. there are still 6 million dogs who have — who need our products or need a derm solution who aren’t getting one.

So we do believe there is still growth in the U.S., although we would expect — although I’m sure, I know in the last years, we’ve seen very strong growth out of the U.S., we would expect over time for the U.S. growth to start to decline the overall growth and more of the growth to come from international. But we still believe there is significant potential in both.

Operator

And our next question will come from Elliot Wilbur with Raymond James. Please go ahead.

Elliot Wilbur — Raymond James — Analyst

Thanks. Good morning, and congratulations on the strong performance of Trio in a challenging year. Kristin, just maybe want to dive in a little bit more on the launch details around the product. Seems like obviously one of the reasons for its relative success this year versus earlier expectations was just far less cannibalization of Simparica than originally expected, but wondering if you could just share with us additional metrics in terms of where you are with respect to clinic penetration rate, how many targeted clinics have you been able to actually reach, just additional metrics around the uptake and launch would be helpful.

Then just thinking about the product longer-term, obviously very strong first year, if I think about launch analogs on the human health side, I mean generally five years out, you’re looking at something on the order of 6x to 10x first year sales. Not sure if that’s applicable in the companion animal market, but just some thoughts in terms of maybe longer-term launch analogs with respect to the product. Thanks.

Kristin Peck — Chief Executive Officer

Sure. With regard to the launch of Trio, I would say there is a lot of unique characteristics of the Trio launch, a, we launched at the height of the pandemic in the U.S., so I’m not sure how to compare that to other people’s launches. We were slower to penetrate clinics I would say in Q2 and Q3, but we’re quite pleased that by the end of the year we reached all of our penetration goals.

So I think our penetration has been quite strong. Given the delay, really the outperformance was our share once we were penetrated within the clinic, the ability to get more of the patients on our product has been really strong and that gives us good confidence as we move into 2021. As Glenn mentioned a few minutes earlier, we are expecting a similar contribution.

For starters, we’ll have a Q1 where we didn’t have sales last year, but with the penetration we were able to achieve by the end of the year, which is reaching the goals we had wanted, we think that we can just get the same pull through that we had at those clinics in 2021, we’ll continue to see a great growth across there.

We’re also seeing it also pull our broader parasiticide portfolio. So I’m not sure I would say I would use a human health analog, but I continue to remind everybody we’re — we remain under-penetrated in this space. And care is the single biggest category in the animal health space, it’s $4 billion globally with $2.5 billion in the U.S. Continuing to see about 15% growth in Simparica beyond Trio, globally, it shows that there’s significant opportunity here for us to continue to grow. And we were quite pleased if you looked at overall care, we had an increase in share of 7% in Q4.

So we think we can continue to take share on this and grow it overall. So I’m not sure it looks like human health. But with our biggest competitors already being $600 million products, I think we’ve got strong ability to continue to grow and to get at least our fair share in this space.

Glenn David — Executive Vice President and Chief Financial Officer

Yeah. I mean, the only thing I would add to that in terms of the question on peak sales, what becomes challenging with peak sales is the timing of competition and that remains unknown. Obviously for 2021, our current guidance does not expect another triple combo within the U.S., and the timing of that will obviously impact what our overall peak sales could do for the product.

Operator

And our next question will come from Navin Jacob with UBS. Please go ahead.

Sriker Nadipuram — UBS — Analyst

Hi, everyone. Thanks for taking the question. This is Sriker Nadipuram on for Navin Jacob. I just have a couple of specific questions. Can you quantify the revenue impact in 2020, be it earlier for cattle run and do you expect this to recur — this adverse negative revenue impact do you expect it to recur in 2021? And then can you quantify the difference in gross margin in diagnostics from your therapeutics portfolio or your corporate average? Thanks very much.

Glenn David — Executive Vice President and Chief Financial Officer

Yeah. So in terms of the impact of the early fall cattle run for 2020, that did not have an impact for the year. That was just a seasonal impact between Q3 and Q4. I think you saw the very strong performance in Q3. You saw the opposite occurred in Q4 of this year. And then predicting the seasonality of that in 2021 obviously is difficult. But we focused more on the full year obviously in terms of the overall impact.

And in terms of gross margin for the diagnostic business, we don’t specifically provide gross margins by therapeutic area or by species, but overall, we always say our companion animal business obviously has the higher margin. Diagnostics in general is lower than some of our key therapeutic areas.

Operator

And our next question will come from David Steinberg with Jefferies. Please go ahead.

David Steinberg — Jefferies — Analyst

Thanks. I have two questions. First is on the rising pet adoptions, obviously one of the tailwinds from the pandemic is decreased adoptions around the country, and around the world. In previous comments, I think you’d said there are about $3.2 million adoptions annually. Just curious now that 2020 is in the books, do you actually have any data, how many more adoptions there were last year and the other tailwind you’ve called out is just increase in dollars per vet visit. And as most pet owners get vaccinated, they go back to work, how durable do you think both the increased dollars per visit and increased adoptions are? And is there any chance that could reverse when most people are back to the office?

And just as a follow-up question on Trio, potential Trio competition, I think Glenn, you said no expectations for competition this year. You previously had said no competition in the first half of this year. When do you actually — I know it’s murky, but when do you actually think there might be your first competitor? And also what gives you such great confidence that there would not be any competition in 2020, when I simply ask that? Because with such a successful launch, it’s obviously a target for any competitors. Thanks.

Kristin Peck — Chief Executive Officer

Sure. With regard to pet adoption, there are 135 million pets in the U.S.. In a typical year, you see about 3.2 million adoptions. So even a 10% increase in that isn’t going to dramatically change things. But we are seeing an increase in vet visits, which we think is a positive trend, and we do expect that to continue in 2021.

So as Glenn mentioned earlier, we did see a 2% increase in vet visits in Q4, we are expecting that to continue. So I think you are seeing maybe proportional to what was the incremental pets that were adopted. We don’t have very specific numbers, but I would say assume it’s somewhere between like 2% and 10% there. It will be helpful, and I do think we’re going to continue to see an increase in visits.

You asked as well about spend per visit, which was incredibly strong in 2020. We don’t believe it’s going to remain that strong to be honest with you, we still think it will grow. If you look generally speaking at our space, you do — we’ve seen overall revenues of clinics growing in the mid to high single-digits on a normal year. I’m not sure what 2021 is going to look like, but assuming it’s somewhere close to a normal year, we do think you’re going to see strong growth overall there in spend, overall revenue into the vet clinic both with growth and total number of visits, as well as spend per visit.

With regards to the Trio question on competition, we don’t have the visibility that human health has as to when we’ll get competitors. To be very frank, we would have expected a competitor by now. We would have expected one in derm as well. So we’re not exactly sure what the challenge is, but we don’t have a great way of knowing other than rumor mill in the market and the strategic accounts who often try to renegotiate with us when they think a competitor is entering the market, which we haven’t seen yet. That does not mean that someone couldn’t surprise us. So there could be, but we wanted to be clear what our guidance was based on.

So at this point, given we don’t have any specific knowledge, we will assume we do not have competition in 2021 and as to when they would come, honestly we don’t really know. But to your point, these are large markets, both your question on Trio, but as well as derm and we are expecting competition. We just at this point do not have any specific knowledge. So our guidance did not include an assumption for competition in either space.

Operator

And we’ll take our next question from Gregg Gilbert from Truist Securities. Please go ahead.

Gregg Gilbert — Truist Securities — Analyst

Hi. Going back to the diagnostics field, Glenn, you mentioned the growth rate there I think 20%-plus. Can you talk about to what degree that rate is influenced by M&A if at all? And maybe more broadly about your strategy there, clearly there is an element of sort of building and catching up, but I’m also curious on sort of how you’re trying to differentiate or leapfrog competition broadly from a diagnostic standpoint?

And then Glenn, are you seeing any signs of upward pressure on key input costs as the world thinks about commodity price inflation or at least the potential for it? Thanks.

Glenn David — Executive Vice President and Chief Financial Officer

So in terms of the diagnostics growth for the quarter like you said, we did see a 20% growth in diagnostics. A part of that was driven by the reference lab acquisitions that we had. So net of that organic growth was around 12% to 13% in diagnostics for the quarter. So, still very positive growth in the quarter and we saw a nice momentum as we move throughout the year and we think that will carry as well into 2021. Also, we established a much better infrastructure for diagnostics in 2020 in two ways. A, we fully integrate it into our core SAP system in the diagnostics business. So we now are able to provide one phase to our customer in terms of billing as well as product offerings.

The other thing that we did was we made significant improvements in our bi-directional connectivity, improving significantly throughout the year. At the beginning of the year, we had that connectivity to about 30%. We increased that at the end of the year to over 70%. So we think that establishes very well as we move into 2021, as well as some of the new innovation we’re bringing with the images platform as well. So we think those are some of the key drivers as we move into 2021, as well as the continued reference lab expansion that we’re embarking on.

So we’re very excited about the growth that we expect to see in diagnostics in 2021. In terms of key input costs and inflation for us from a manufacturing perspective, there’s nothing in particular that we see particularly challenging. Obviously for 2020, we had some elevated freight costs because of the impact of COVID-19. That will probably continue as we move into 2021. That is embedded in our guidance, but nothing else of a significant impact.

Operator

And there appears to be no further questions at this time. I will turn the call back over to the speakers for any additional or closing remarks.

Kristin Peck — Chief Executive Officer

Thank you. Thanks everybody for your questions and your continued interest in Zoetis today. We look forward to keeping you updated on our business throughout the year and continuing to deliver the results and innovations that you and our customers expect. Thanks so much for joining us.

Operator

[Operator Closing Remarks].