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Bicycle Therapeutics (BCYC) Q4 Revenue Soars 1194.5% YoY to $48M, Crushing Estimates by 578%

Bicycle Therapeutics narrows Q4 loss to $0.29/share vs $0.95 estimate; revenue of $48M crushes $7.1M consensus by 578%.

March 17, 2026 2 min read
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Bicycle Therapeutics narrows Q4 loss to $0.29/share vs $0.95 estimate; revenue of $48M crushes $7.1M consensus by 578%.

Earnings Per Share (GAAP)
$-0.29
vs $-0.95 est.
Revenue
$48.0M
vs $7.1M est.

Loss narrows sharply. Bicycle Therapeutics plc (NASDAQ: BCYC) reported a loss of $0.29 per share for Q4 2025, narrower than the estimated loss of $0.95, 69.6% narrower. The biotechnology company posted a net loss of $20.2 million for the quarter. Eleven analysts had projected losses ranging from $0.79 to $1.18 per share. The result marks significant improvement from the year-ago loss of $0.81 per share.

Revenue surges past consensus. Revenue reached $48.0 million, crushing the $7.1 million analyst consensus by 578%. The top-line figure represents a dramatic acceleration from the prior quarter’s $48.0 million and the year-ago period’s $3.7 million. Analyst estimates had ranged from $2.9 million to $15.0 million, with the actual result exceeding even the most optimistic projection by more than threefold.

What to Watch: The company’s ability to sustain this revenue trajectory in Q1 2026 will determine whether the $48 million quarter represents a new baseline or a one-time milestone payment. Watch for management commentary on the earnings call regarding revenue composition and forward guidance.

This article was generated using AlphaStreet’s proprietary financial analysis technology and reviewed by our editorial team.

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Tags: #BCYC