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LXRX Reports Mixed Q4 Results: Loss Improves to $0.04 Per Share But Revenue Crashes 79% YoY

Lexicon narrows Q4 loss to $0.04 per share, down 55.6% YoY, but revenue plunges 79% to $5.5M amid biotechnology sector headwinds.

$LXRX March 6, 2026 1 min read

NYSE

$LXRX · Earnings

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Lexicon narrows Q4 loss to $0.04 per share, down 55.6% YoY, but revenue plunges 79% to $5.5M amid biotechnology sector headwinds.
vishnu · March 6, 2026

Loss narrows sharply. Lexicon Pharmaceuticals reported a loss of $0.04 per share for Q4 2025, narrowing 55.6% from the $0.09 per share loss in the year-ago quarter. The biotechnology company posted a net loss of $15.5 million for the quarter, with operating losses of $14.8 million partially offset by gross profit of $5.3 million.

Revenue collapses year-over-year. Q4 revenue totaled $5.5 million, down 79.3% from the prior-year quarter. Cost of revenue remained minimal at $201 million, suggesting the company maintained strong gross margins despite the sharp revenue decline. The stock traded flat at $1.61 following the release, with volume of 2.4 million shares.

Earnings Per Share

$-0.04

estimate N/A

Revenue

$5.5M

estimate N/A

What to Watch: The company held its earnings call at 8:30 AM ET on March 5. Investors should monitor management commentary on the revenue trajectory and cash runway, particularly given the 79% year-over-year revenue decline paired with ongoing operating losses. The path to profitability and any pipeline updates will determine whether the narrowing loss trend can continue.

This article was generated using AlphaStreet’s proprietary financial analysis technology and reviewed by our editorial team.

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