Quest Diagnostics Inc (NYSE: DGX) Q4 2025 Earnings Call dated Feb. 10, 2026
Corporate Participants:
Shawn Bevec — Vice President of Investor Relations
James Davis — Chairman, Chief Executive Officer & President
Sam Samad — Executive Vice President & Chief Financial Officer
Analysts:
Luke Sergott — Analyst
Patrick Donnelly — Analyst
Michael Cherny — Analyst
Kevin Caliendo — Analyst
Jack Meehan — Analyst
Erin Wilson Wright — Analyst
Michael Ryskin — Analyst
Tycho Peterson — Analyst
Andrew Brackmann — Analyst
Elizabeth Anderson — Analyst
Benjamin Shaver — Analyst
Yujin Park — Analyst
Presentation:
operator
Welcome to The Quest Diagnostics fourth quarter and year end 2025 conference call. the request of the company, this call is being recorded. The entire contents of the call, including the presentation and the question and answer session that will follow, are the copyrighted property of Quest Diagnostics with all rights reserved. Any redistribution, retransmission or rebroadcast of this call in any form without the written consent of Quest Diagnostics is strictly prohibited. Now I’d like to introduce Shawn Bevig, Vice President of Investor Relations for Quest Diagnostics. Please go ahead.
Shawn Bevec — Vice President of Investor Relations
Thank you and good morning. I’m joined by Jim Davis, our Chairman, Chief Executive Officer and President, and Sam Samad, our Chief Financial Officer. During this call we may make forward looking statements and will discuss non GAAP measures. We provide a reconciliation of non GAAP measures to comparable GAAP measures in the tables to our earnings press release. Actual results may differ materially from those projected risks and uncertainties that may affect Quest Diagnostics. Future results include, but are not limited to, those described in our most recent annual report on Form 10K and subsequently filed quarterly reports on Form 10. 2 and current reports on Form 8K.
For this call, references to reported EPS. Refer to reported diluted EPS and references to adjusted EPS refer to adjusted diluted eps. Growth rates associated with our long term Outlook projections, including consolidated revenue growth, revenue growth from acquisitions, organic revenue growth and adjusted earnings growth are compound annual growth rates. Now here’s Jim Davis.
James Davis — Chairman, Chief Executive Officer & President
Thanks Dan and good morning everyone. With diligent execution of our strategy and a strong fourth quarter, we generated double digit growth in revenues and earnings per. Share for the full year. In 2025, we expanded our category defining clinical innovations to meet robust demand, formed strategic collaborations with elite healthcare organizations and further advanced our position as the premier lab engine powering the wellness industry. We also continue to improve quality, productivity and the customer and patient experience with process enhancements, AI and automation as we look ahead to 2026. Our guidance reflects our continued confidence in our business strengths and market fundamentals which include favorable demographic trends, increasing use of blood based lab diagnostics and growing interest in preventative health and wellness. Now, before I turn to this year’s highlights, I’d like to take a moment.
To comment on pama. Last week, bipartisan legislation was enacted that delays the implementation of PAMA until the end of 2026. This one year delay in rate cuts was paired with an update to the data collection period to the first half of 2025 from the first half of 2019 based on the data to be supplied by applicable laboratories to CMS later this year. We greatly appreciate Congress for recognizing the need to reform PAMMA and for providing this one year delay of PAMA cuts which provides meaningful short term relief. However, these steps do not fix Pama’s structural flaws which include relying on an estimated 10,000 plus labs to self report data to establish industry representative data for payment rate setting.
As a reminder, fewer than 1% of all the clinical laboratories reported commercial payer data to CMS in 2017 resulting in three rounds of excessive rate cuts based on data that did not reflect the market. A different approach is needed to prevent a repeat of excessive rate cuts. The Results act provides a common sense long term solution that corrects these deficiencies by, for example, eliminating the need for thousands of labs to self report data and instead leveraging an independent third party database that provides comprehensive and representative data to set accurate market based rates. We will continue to work with our trade association ACLA to build on progress in securing the necessary support in Congress to pass results into law this year.
Now I’ll provide more detail on how we executed our strategy across our key customer channels and operations. During the quarter and the year, we are focused on delivering solutions that meet the evolving needs of our core clinical customers, physicians and hospitals, as well as customers in the higher growth areas of consumer life sciences and data analytics. In the physician channel, we delivered high single digit organic revenue growth in the fourth quarter on broad based demand for our clinical solutions including several areas of advanced diagnostics and and from geographic expansion resulting from increased health plan access.
We also grew revenues in enterprise accounts as we added new customers and extended business with existing customers. In addition, during the quarter we scaled our lab testing to serve more than 200,000 patients at Fresenius Medical Care’s dialysis centers in the United States. We also added water purity testing capabilities to our menu to support dialysis customers nationwide. In the hospital channel, revenues grew low single digits. With collaborative lab solutions driving our growth in the quarter, our COLAB solutions harness our lab and process management expertise to optimize quality and drive cost efficiencies in areas ranging from hospital lab and supply chain management to analytics and blood utilization.
At the start of 2026, we began to scale our CO lab Solutions across all 21 hospitals of Corw Health, a leading health system in Michigan and our largest implementation of these solutions to date. We expect COLAB solutions to generate approximately 1 billion in annual revenues in 2026. Additionally, we recently finalized our laboratory joint venture with Corewell Health and are jointly constructing a state of the art laboratory in Southeast Michigan from which we plan to serve the state in 2027. Hospitals value our flexible solutions for accessing expertise, innovation and capital. We are pursuing several potential hospital outreach and independent lab acquisitions as well as COLAB opportunities while also continuing to integrate and generate value from our recent transactions in the Consumer Channel we are leveraging our diagnostics expertise and technology to drive growth through our consumer initiated test platform questhealth.com as well as through collaborations with industry leading wellness and wearables companies.
In the fourth quarter, we expanded questhealth.com to offer more than 150 tests including our new 85 biomarker elite health profile. Our innovation, quality and technology integration into existing apps and experiences make us the clear choice for organizations seeking to add diagnostic insights to their offerings and and we added new consumer brands to our extensive roster of collaborations in the fourth quarter. At our investor day in March last year, we said that we would expect consumer initiated testing to generate revenue growth in excess of 20% and we exceeded that growth rate in 2025. Across the consumer channel, we delivered nearly $250 million in revenues for the full year.
We enable growth across our customer channels through faster growing advanced diagnostics in five key clinical areas advanced cardiometabolic and endocrine, autoimmune, brain health, oncology and women’s and reproductive health. During the quarter and full year, we delivered double digit revenue growth across several clinical areas of our advanced portfolio. I’d like to highlight a couple of these innovations today. Our Analyzer solution provides a comprehensive yet simple approach for aiding the diagnosis of the eight most common autoimmune disorders. About 24 million Americans suffer from at least one of over 100 autoimmune disorders. Because symptoms of these disorders often overlap and a shortage of rheumatologists exist nationwide and patients may go for years before receiving the correct diagnosis.
Analyzer helps primary care clinicians identify the likely category of disease affecting the patient and thereby speeding referral to the right specialist for faster diagnosis and treatment in brain health. Our portfolio of Quest AD Detect blood tests for Alzheimer’s disease extended its year long double digit growth momentum into the fourth quarter as providers increasingly adopted the high quality blood based biomarker tests for the most prevalent type of dementia. A recent study by our scientific team suggests that blood tests like our newest AD Detect Panel, which fulfills guideline criteria for confirmatory blood testing, could decrease cost to the healthcare system by reducing the use of higher cost PET CT imaging for diagnosis, improving access and affordability in oncology, we continue to build our presence in Blood Based Minimal Residual Disease Testing New research presented at ASCOGI in early January highlighted the strong clinical value of our Haystack MRD test in monitoring for colorectal cancer.
We further expanded in the MRD space with the launch last week of our cutting edge flow MRD test for blood based cancer myeloma. This test enables ultrasensitive detection of residual disease in a blood specimen, sparing patients the pain and complications of conventional testing. Of bone marrow biopsies. Along with driving top line growth across our business, we are focused on delivering operational excellence with enhanced processes and strategic implementation of automation, AI and other advanced technologies. Through our Invigorate program, we achieved our full year target of 3% annual cost savings and productivity improvements in 2025. Inside our labs, we deployed automated sample processing across our network and collaborative accessioning at multiple sites to streamline and optimize our processes. We also implemented the Hologic Genius digital Diagnostic system at two of our laboratories and look forward to scaling the solution for enhancing quality and productivity in cervical cancer screenings at several of our labs this year.
Outside the lab, we’re using AI to make the customer and employee experiences easier, faster and more insightful. For example, our virtual AI agent has reduced routine logistics calls by up to 50%, and we expect a new AI logistics tool will help us reduce courier transportation times as we roll it out this year. And now, Sam will provide more details on our performance and our 2026 guidance. Sam
Sam Samad — Executive Vice President & Chief Financial Officer
thanks, Jim. In the fourth quarter, consolidated revenues were $2.81 billion, up 7.1% versus the prior year. Consolidated organic revenues grew by 6.4%. Revenues for diagnostic information services were up 7.3% compared to the prior year, reflecting organic growth in our physician, hospital and consumer channels as well as recent acquisitions. Total volume measured by the number of requisitions increased 8.5% versus the fourth quarter of 2024, with organic volume up 7.9%. Total revenue per requisition was down 0.1% versus the prior year. As a reminder, Corewell Health and Fresenius Medical Care deliver significant volume growth at a lower revenue per acquisition than our company average.
Excluding these two relationships, our organic volume growth accelerated to 4.1% in the fourth quarter, while our revenue per requisition growth remains solid at approximately 3%. Unit price remained consistent with our expectations. Reported operating income in the fourth quarter was $386 million, or 13.8% of revenues, compared to $361 million, or 13.8% of revenues last year on an Adjusted basis operating income was $429 million or 15.3% of revenues, compared to $409 million or 15.6% of revenues last year. The adjusted operating income dollar increase was due to organic revenue growth and revenue growth from recent acquisitions, partially offset by wage increases.
Operating income percent was reduced in the quarter by startup expenses related to Fresenius Medical Care and Corewell Health as well as Project NOVA expenses. Reported EPS was $2.18 in the quarter and adjusted EPS was $2.42 compared to $1.95 and $2.23 the prior year respectively. Foreign exchange rates had no meaningful impact on our results. Cash from operations was $1.89 billion for the full year 2025 versus $1.33 billion in the prior year. This significant year over year increase was driven by higher operating income, favorable working capital due to timing of disbursements, a cash tax benefit related to recent tax legislation and the one Time CARES act tax credit.
As Jim said, we successfully executed on our strategy in 2025 to deliver these results and we will continue to build on this as we progress through 2026. Turning now to our full year 2026 guidance, revenues are expected to be between $11.7 billion and $11.82 billion which represents a growth rate of 6% to 7.1%. Reported EPS is expected to be in a range of $9.45 to $9.65 and adjusted EPS in a range of $10.50 to $10.70. Cash from operations is expected to be approximately $1.75 billion. Capital expenditures are expected to be approximately $550 million. Our share count and interest expense are expected to be consistent with 2025.
This guidance reflects the following considerations. We assume approximately 6% to 7.1% in revenue growth and this does not include any contribution from prospective MA. The severe weather impact experienced in January 2026 is creating a greater headwind than what we experienced during the same period a year ago. We have contemplated the impact to date in our full year guidance, we expect the seasonality of our business to be generally in line with last year’s and pre Covid seasonality. Based on the passage of federal funding legislation last week, there will be no impact from PAMA in 2026. For Project Nova, our multi year initiative to modernize our order to cash process, we expect approximately $0.25 of EPS dilution related to increased investment spend versus 2025 operating margin is expected to expand versus the prior year.
The CoLab relationship with Corewell Health will add approximately $250 million in organic revenue at low single digit margins in 2026. We continue to make progress with our launch of Haystack MRD and expect it will be less dilutive versus the prior year as we ramp volumes. We expect our adjusted effective tax rate to increase approximately 100 basis points in 2026 versus 2025. Our lower operating cash flow guidance in 2026 compared to 2025 reflects several one time benefits in the prior year and one more payroll cycle in 2026 than 2025. The one time benefits in 2025 were approximately $150 million and the impact of the one additional payroll cycle in 2026 is approximately $120 million.
With that, I will now turn it back to Jim
James Davis — Chairman, Chief Executive Officer & President
Thanks Sam. To summarize, with diligent execution of our strategy and a strong fourth quarter, we generated double digit growth in revenues and earnings per share for the full year. In 2025 we delivered category defining clinical innovations that fulfill customer needs, form strategic collaborations to create new growth opportunities and and further advanced our position as the premier lab engine in consumer health. Our 2026 guidance reflects our continued confidence. In our business strengths and market fundamentals supporting enduring interest in our diagnostic innovations. Looking ahead, I’m excited about our path forward. We are focused on connecting everyone from clinicians to consumers to illuminate a path to better health and are well positioned to serve growing interest in accessing the health insights that only laboratory diagnostics can deliver. Quest sits at the center of healthcare as a trusted provider and that’s because of the dedication of our nearly 57,000 colleagues to living our purpose, working together to create a healthier world one life at a time. I’d like to close by thanking each of my colleagues for what we accomplished together in 2025 and for their ongoing commitment to transforming lives for the better in the years ahead.
Now we’d be happy to take your questions Operator.
Questions and Answers:
operator
Thank you. We will now open up to questions. At the request of the company, we ask that you please limit yourself to one question. If you have additional questions, we ask that you fall back in the queue. To be placed in the queue, please press Star 1 from your phone. To withdraw, press Star 2. Again. To ask a question, please press Star 1. Our first question comes from Luke Surgat with Barclays. Your line is open. You may ask your question.
Luke Sergott
Great. Thanks for the questions guys. I guess as you’re looking for 26, can you give a sense of what the underlying growth drivers are as you think about or the assumptions on the growth drivers. You think about the consumer piece, new tests as you think, you know, MRD coming on, potential reimbursement there, chronic disease management, et cetera. You know, just kind of break it out as to what you guys are thinking from the. As we kind of bridge that build.
James Davis
Yeah. Hey, good morning, Luke. I think you touched on most of those. Look, we expect the organic growth to remain strong as Sam indicated. I think from a testing standpoint, you know, we’re seeing tremendous uplift in our Alzheimer’s portfolio of tests. Those include the AB4240, several P Tau markers, as well as our algorithms that assess the likelihood of disease. Our autoimmune testing, as I indicated in the script, is again, very, very strong. The new diagnosis rate of autoimmune disorders continues to grow. Diabetes continues to grow. Cardiovascular testing, and not just the routine testing, the, the more advanced testing, what we call cardio iq that includes LP apob, insulin resistance, all of those doing very, very well.
Some of that being generated by the consumer segment. Our own questhealth.com just saw tremendous growth throughout last year. The partnerships that we developed with whoop, with Aura, with Function Health, with several other types of wellness companies, all of that helping. The last thing I’d mention is, you know, we got back into network with elevance in several key states last year. Nevada, Colorado, Colorado, Georgia and Virginia. And I’d still say we’re in the early innings of winning our fair share in those states. So all of that continues to just, you know, propel the organic growth as we enter this year.
Luke Sergott
Great. And then a follow up here, as you think about 1Q, you talked about the bigger weather impact, that headwind. You think about consumer ramping. And just from a pacing perspective, how are you guys thinking about 1Q and then how that ramps throughout the year?
James Davis
Yeah. Let me just comment on the weather impact. It was a tough January versus last January, but the good news is it was in January. So we have the rest of the quarter, the rest of the year to make it up. Now, you know, we can’t predict the weather in the last six weeks of the quarter here, but what I’ll tell you is, you know, the first three, three and a half weeks of January were very strong, very strong growth. And so we’re convinced that the majority, some portion of it comes back, you know, whether it’s 30%, 40%, it’s hard to predict.
The general health and wellness types of work always comes back to us. Some of the episodic Work. If people were getting tested every two weeks for some chronic care condition, maybe they missed that appointment. But the other thing I’d tell you is we have really good systems in place today to track the appointments that were canceled, to track the appointments that we canceled because we couldn’t open our patient service centers. And we continue to remind patients that they missed their appointment. And we see nice uptick from those reminders. In terms of patients reschedule, in terms.
Of the pacing of the quarter, I’ll. Let Sam comment on that.
Sam Samad
Yeah. So, Luke, I mean, I’d echo first of all the comment that Jim made around very strong utilization in the first part of January. And then we had some real historically bad storms across the country that impacted the month. But we’re still confident about the recovery in the quarter. And what we’re seeing is also that strength coming back. But in terms of seasonality, you know, I think what you should expect is something similar to what we saw last year in terms of pacing across the quarters over the full year, and something similar to what we saw pre Covid seasonality.
If you go back before 2020, specifically referring to the 2016, 2019 period, that type of seasonality is very, I would say, consistent in our business. It was disrupted during COVID but if you Compare it to 25, I think the seasonality is. Is very similar in terms of how you should think about the pacing.
James Davis
Great operator. Next question.
operator
Thank you. Our next question comes from Erin Wright with Morgan Stanley. Your line is open. You may ask your question. Aaron, your line is open. Please check your mute feature.
James Davis
Let’s go to the next question.
operator
Thank you. Our next question. Then comes Patrick Donnelly with Citi. Your line is open. You may ask your question.
Patrick Donnelly
Hey, guys, thank you for taking the questions. Sam, probably one for you. I just want to talk through the moving pieces on the margins. It seems like a lot is going on in 26 between CoreWell, Project, Nova, Haystack, an extra week of the payroll, which you mentioned. It does sound like they’ll be slightly up year over year. So can you talk through the impact? A little bit of a bridge if you’re able to. And then the cadence, it sounds like typical seasonality. I know typically 2Q is the highest. It will be helpful just to talk to the cadence and then the moving pieces on the margins.
And if you’re able to quantify, that would be even better. Thank you, guys.
Sam Samad
Yeah, thanks, Patrick. So let me. Let me go through all the moving parts here. At least the moving parts that we have in 26. First of all, let me just say operating margin is expected to increase in 26 versus 25. So that’s the starting point here in terms of how you think about 26. It is impacted somewhat negatively by the ramp of Corewell and Fresenius businesses, mostly Corewell. Actually in terms of the roughly $250 million of Corewell revenue increasing in 26 which comes at a lower margin. It’s a collab business. It’s low single digit margin in 26 improving to, you know, normal colab margins later in 27 and beyond.
But in 26 it’s impacting operating margin rate. It is very good business. It’s 250 million in terms of additional revenues but at low single digit margins this year. So that’s impacting the operating margin rate expansion. But even with that, operating margin rate is improving. Obviously we have very strong organic volumes. The 6.6% at the midpoint guide that we’ve given is mostly organic growth. It’s almost all organic growth actually. There’s only about, you know, roughly 15 basis points of M and a carryover in that. So think about it as all organic growth and driving margin expansion there.
You know, in terms of price impact, again another piece of the story here. Price is relatively flat year over year, consistent with our expectations and consistent with what we’ve been seeing in practice over the last couple of years. So, you know, no negative impact from price roughly flat within that plus or minus 30 basis points that we’ve talked about. You know, in terms of Haystack, Haystack is less dilutive in 26, so it’s actually helping. You know, that’s consistent with what we’ve shared in terms of 26. So the test is ramping, good volume ramp. That leads to less dilution on Haystack and then you know, you have on as an offset project Nova.
We’ve quantified that in the guide that we provided. It’s roughly 25 cents of incremental expenses in 26 that’s impacting our margins. So that’s going to happen across 2026. It started to ramp more significantly in Q4 of 25 and it’s going to continue in 26 as we stated prior and we’ve quantified it now for 26 in terms of seasonality. The last thing I think that you asked Patrick, and then I’ll hand it over to Jim who wanted to add a couple of comments. But you know, seasonality consistent with what we saw last year. But if you think about it in. Terms of maybe more Specific terms across the quarters. You know, Q1 is usually our weakest quarter as we say in terms of EPS contribution to the year. Q2 is the strongest quarter, Q3 is a step down from Q2 and Q4 is a step down from Q3. In terms of seasonality, first half, second half, I think you should expect somewhere just north of 49% in the first half and just north of 50% in the second half in terms of EPS contribution to the full year. That’s just giving you more specifics. That’s the seasonality pacing. Jim?
James Davis
Yeah Patrick, A couple of the things that are enhancing the margins margin rate. One is our consumer business. We mentioned in the script. It’s a 250ish million dollar book of business that continues to grow at 20%. Remember with that business there’s no denials and there’s no patient concessions or bad debt. It is definitely a help from a margin margin rate standpoint as we continue to grow that business north of 20% relative to the portfolio growing 6 to 7%. The other thing I would mention is Life Labs in Canada, the margin rate continues to improve. We said by year three it would be at the company average and it is definitely heading in that direction.
Very close to that. And as that margin rate of that business continues to improve, it will help our margin rate as well. Great operator. Next question.
operator
Thank you. Our next question comes from Michael Cherney with Lyering Partners. Your line is open. You may ask your question.
Michael Cherny
Good morning and thanks for taking the question. Maybe if we can talk about the competitive environment as you see it and you talked obviously about above expectations organic growth. Some of these are contract oriented. But as you think about the current health of the market, think about where you sit across the hospital labs and environment where you continue to have different types of partnerships. Where do you see your biggest competitive strengths are as you kick off in 26 and 27 and how much of the expectations for organic growth are for lack of a better term, share gains.
James Davis
Yeah. Hey Mike, look, I think there’s absolutely share gains in the organic growth that we saw in 2025 and I think it’ll continue into 2026. As I mentioned, getting back into network in those key states with elevance, that’s all share gain in those states. I didn’t mention Sentara, but Sentara is a big health system health plan in the Southeast along the Atlantic coast. We are back in network with them and that’s been a tremendous help. Look, our strengths are simply our national coverage. We have over 1200 sales reps out there positioned with primary care with all of the various channels.
And that really helps when it comes to, you know, positioning our autoimmune testing, our brain health testing, our cardiometabolic testing, having that broad national coverage really, really helps. Now in terms of, you know, everyone wants to make a lot about, you know, Quest and our nearest competitor, but I got to tell you what, Quest and our nearest competitor are probably less than 25 the market. 30% less than 30% of the market. So I think we’re making inroads versus hospital outreach. I think we’re making inroads against physician office labs. And you know, perhaps these big health systems are just, you know, not as, you know, not going after that business as strongly.
Right. They have other things to invest in. They have other priorities, other, you know, investments that generate higher returns and than laboratory testing. So I think we’re capitalizing on those trends.
Shawn Bevec
Great operator. Next question.
operator
Thank you. Our next question comes from Kevin Caliendo with ubs. Your line is open. You may ask your question.
Kevin Caliendo
Hi, thanks for taking my question. What are you guys seeing in terms of the hiccs now that we have further visibility? Is that sort of in line with. Your original expectations around the potential impact. And just a clarifying question around volumes. I appreciate that you’re now including Fresenius. And Corewell in this, but if we. Were to take that out, what would. It have been and what would your organic sort of volumes been in 4Q?
Sam Samad
Yeah, sure, Kevin, let me comment on both and Jim can add color as well. But first on the health exchanges, I’ll remind you about what we modeled and what our expectations are. We modeled a 30 basis point impact on growth, on revenue growth from the exchanges. So and that’s factored into our guide for the year. So that was our modeling and that’s what our expectation is. Now in reality, what we’ve seen in terms of enrollments has actually been better than expected. It’s early days to measure utilization as a result of that and what the loss of utilization is off of the enrollments.
But I would say we’re encouraged by what we saw so far in terms of by the end of the year and also what we saw in January in terms of enrollments. Now again, we need to see the mix of those enrollments of potentially patients going to higher deductible plans, bronze plans versus gold plans. I mean there’s a lot of moving parts there and it’s very early days to be able to say, you know, this is, this is really encouraging. But so far based on the enrollments, we’ve seen it better than expected. You know, in terms of the.
You asked about Fresenius and Corewell. Listen, both of these are. Corewell is all organic growth. It’s a collab relationship. It’s all organic growth. Fresenius is mostly organic growth as well. You know, in terms of. We did talk about the fact that. In Q4, you know, where our DIS business grew by roughly close to 8% organically in terms of volumes, the volume growth X for Senius and Corewell was just over 4%. So basically from a volume perspective, you know, they had a sizable impact because the nature of the Fresenius business specifically and to some extent Colwell. But more so Fresenius is. It’s very routine business, very high volume business that’s done on a very regular basis. It’s a lower rev per rev business, still very profitable. Based on the fact that we don’t do draws, we don’t incur as much cost, but it’s a high volume business.
The impact on revenue in Q4 was much less. It was just less than a percent. So our organic revenue growth was 5.6% excluding those two businesses. And it was 6.4% in total.
James Davis
Yeah, Kevin, the other thing I’d point out is in addition to the 4.1% organic growth, when you strip out Fresenius in Corewell, we also had 3% organic rep per rec left. And again that’s coming from price being stable, number one. Number two, the continued test per req increase. We’re seeing some of that coming from the mix of our consumer business. So all of that just continues to point to strong organic revenue growth that we’re seeing.
Sam Samad
Operator, next question.
operator
Thank you. Our next question comes from Jack Meehan with Nephron Research. Your line is open. You may ask your question.
Jack Meehan
Thank you. Good morning, guys. Jim, wanted to ask you about how you see PAMA playing out this year. So we do have the survey coming up from May through July. I assume. Like are you ready to participate in that? And do you think this data ultimately is read out later in the year. And could inform rates in 2027?
James Davis
Yeah. So first check. We’re really thankful that we got a delay for the sixth year in a row. And I think that is reflective of the fact that Congress feels that the original methodology was flawed and it led to excessive cuts and that’s why we got the further delay. As you indicated, they moved the data collection process from 2019 to 2025. And yes, we’re absolutely prepared to report. The problem, Jack, is I’m not sure the other 10,000 labs, maybe there’ll be a few, are prepared to report. So if we end up with less than 1% of the labs reporting like what happened before, it’s just going to lead to inaccurate market based pricing.
So that’s why we continue to push the Results act and we remain optimistic that the act will get, for lack of a better word, acted on this year. There was a hearing on January 8 with the Energy and Commerce Committee. The health subcommittee, our acla president testified at that meeting. There’s over 65 co sponsors of the bill. And as you know, under the Results act, that leads to a different type of data collection process, one that uses a third party database. There’s many third party databases out there. The one we’ve recommended represents a sample of over 80% of the adjudicated laboratory recs.
And we think that’s going to be a much better indicator of what the market price will be. And when you mix in the roughly 9,800 labs that failed to report the last time, and those are labs that are primarily hospital outreach labs, physician office labs, other smaller independent labs, when you mix all that data into the two largest national labs, we think it is good news for the calculations related to the absolute market rate of the testing that is out there today. So we’re optimistic, but we’re going to keep pushing it hard in the first six months of this year and hopefully get it done before the fall.
Shawn Bevec
Great operator. Next question.
operator
Thank you. Our next question comes from Erin Wright with Morgan Stanley. Your line is open, you may ask your question.
Erin Wilson Wright
Great. Sorry for the issue earlier, but can we dig into some of the consumer testing dynamics in the environment that you’re seeing? You’ve launched several new partnerships, new initiatives, himss, Aura, Function Health. Like what do you. Can you speak to some of the sustainability of growth across this segment? The margin profile? Are you seeing anything new or different in terms of consumer utilization trends across this segment? And how should we think about what’s embedded in guidance in 2026 on this front?
James Davis
Yeah, so thanks, Erin. We remain very optimistic about this. You know, this is all about consumers who are interested in their own health. They’re interested in prevention. And as you know, prevention is not about waiting for symptoms. Prevention is doing some things before diagnosis being doing something before symptoms set in. Let me start with the wearable companies. I think this notion of linking your biometrics with your biomarkers so that you understand the influence of those Biometrics, whether it’s sleep, nutrition, movement, heart rate, variability, pulse, you can create these correlations between those biometrics and your biomarkers, ultimately giving feedback to the consumer on what they need to do in order to improve their biomarkers.
And I think these wearable companies are really onto it. And we’re seeing, you know, nice lift from still very early with both those companies, but we’re seeing nice lift, I think some of our value added resellers that are providing, let’s just say other value added medical guidance to the laboratory testing that we do for them. I think it’s serving the need, honestly, that consumers can’t get or aren’t getting from their physicians. You know, many of the tests on these panels won’t be covered by normal health plans under normal conditions, under normal general health and wellness testing.
And yet these same tests are covered if the patient is sick. So again, people are worried about prevention, not waiting until they get sick to get these types of tests. So look, we’re looking at the renewal rate of these companies. Many of these value added resellers are subscription based. And we look at the renewal rates and we’re positive about what we’re seeing. The last thing I’d leave you with is our own questhealth.com channel is on $100 million. It’s $100 million run rate business right now. And we continue to see nice uptick there. And it’s not just in the wellness panels that we offer on questhealth.com, but.
There’S a lot of what I call. Episodic testing that occurs. This could be allergy testing, tick testing. This could be diabetics who just want to check their A1C. It’s a lot of STD testing. So our own channel continues to grow very nicely and we certainly look at the repeat business of our own consumers and are happy with that.
Sam Samad
Maybe I’ll add a couple of comments, Erin, just on the financial side. So with regards to the direct consumer that Jim just mentioned, the questhealth.com you know, we’ve talked about that business growing somewhere in the 35% range over the course of the year. And that’s in fact where it ended, is approximately 35% for the full year, 25. So that business is really doing very well. And then if I think about the direct consumer, but also the partnerships that we have, and the partnerships are wearables and other wellness companies, et cetera, we’ve got a vibrant ecosystem there that we’re supporting and that we are the engine for the margin rates on those businesses.
Both direct and the other collaborations that we have is an attractive margin rate above our corporate average because basically it’s simple, it’s all cash pay. We don’t have patient concessions, we don’t have denials. So that business is an attractive margin profile. You asked about guidance for 26. I mean not going to give you specific number but you know, all I’ll say is that that greater than 20% growth in terms of a CAGR over the long term we still feel very confident about in terms of consumer and these other high growth business that we called out during investor day.
And you know, the expectation this year is that we’re going to continue to sign up new partners as well and collaborations because you know, we are powering a whole ecosystem here. Operator, next question.
operator
Thank you. Our next question comes from Michael Rifkin with Bank of America. Your line is open, you may ask your question.
Michael Ryskin
Hey, thanks for the question guys. I want to go back to Corwell and FreshEnia’s contribution in 26. Just given that it’s organic and that’s sort of like traditional M and A basket. But I also want to focus on margin opportunity and the ramp there over time. I know you talked about sort of dilutive margins and price in 2026 and improving over time. Could you just walk us through the ramp and what gets you there and just sort of give us a sense for the time frame for both of those businesses going beyond this year. Thanks.
James Davis
Yeah, I think it’s pretty straightforward. Michael. On Corewell we said it’s a 250ish million dollar book of business for us in 2026. And we said in total and we said that that would start out at low single digit margin rate. As we get into 2027, we expect that to be in the low teens. Fresenius, the margin rate will continue to improve through the end of the year and by the end of the year we expect that book of business to be at or slightly above the company operating margin rate average. Okay.
Michael Ryskin
Next question. Go ahead.
Sam Samad
Go ahead, Michael, go ahead.
Michael Ryskin
Sorry, just real quick, is that when we think about the moving pieces to the margins in 2026 you talked about, you know, margins will grow this year but you know, it sounds like it’s a little bit less than we would have expected in prior years. Is that the biggest swing factor or is there something else that we’re keeping in mind for margins this year?
Sam Samad
I think the Corewell one is the biggest swing factor. The fact that it’s a 250 million incremental business at low single digit margin. So that is definitely a swing factor for Sanius as Jim mentioned. I mean think about it as kind of a similar, somewhat similar profile to a physician outreach acquisition where it starts out below the margin average. You know we’ve got integration costs, we’ve got some setup costs and then over time maybe takes it longer than a typical physician outreach acquisition. But over time it improves and by the end of the year I think we’ll be at the average.
The only other thing I’d point to which I mentioned earlier when I answered Patrick’s question is NOVA expenses and the fact that we have an incremental 25 cents of Nova expenses in 26. But you know, we still have healthy operating margin rate expansion impacted to some extent by the corewell growth. But corewell will ramp over time to improve the normal COLAB margin rates. Operator, next question.
operator
Thank you. Our next question comes from Tycho Peterson with Jefferies. Your line is open, you may ask your question.
Tycho Peterson
Hey thanks a couple on oncology. So Haystack, you’ve got the bold X reimbursement decision effective January 1st. Maybe just touch on the path to getting commercial coverage Medicare Advantage. Some of the next steps we should be thinking about on the back of MoldX and then on the flow cytometry based MRD test. I’m just curious how you think about the value proposition there. Obviously more of that market is moving towards sequencing based tests. And then just lastly, are you baking anything in for your multi cancer risk stratification test launching this year? And what about the partnerships with Garden and Grail? Thanks.
James Davis
Yeah, so there’s a lot there Tycho. Look, with respect to Haystack reimbursement, Novitas is the Mac that we submit to and it did receive a PLA code. It received reimbursement. We continue to adjudicate through Novitas and are successful there. With respect to Medicare Advantage, we’re still waiting on the multi X tech assessment. Once that tech assessment is complete the first we will be well positioned with the Medicare Advantage plans. And then you know, look, we’re having ongoing discussions with all the major payers in terms of commercial reimbursement. In some cases we get paid, in other cases you don’t.
And some, you know, we appeal them all. We have doctors write letters around medical necessity and we continue to make progress on that. Look, the flow MRD is an ultra sensitive flow test that has incredibly good sensitivity specificity and we think it is very, very competitive with, you know, with next gen sequencing based tests, we’re very confident of that. We’ll continue to do studies to show that the value proposition is really around speed. So as you know, patients with myeloma, you know, that disease moves very, very quickly. Speed is of the essence and we can get an answer back within three days.
It’s also a significantly lower cost test. So from a reimbursement standpoint, it’ll offer payers a choice. It’ll offer physicians and patients a choice to have a test that is highly comparable with the next gen sequencing test and again, a turnaround time that is very, very short. Three days, not weeks. And with again, ultra good sensitivity, specificity in terms of the multicancer early detection test. Yes, we have a partnership with Grail. We will do the blood draws for Grail. We’ve listed it in our test compendium and Grail obviously pays us to do those draws and handle the logistics for them.
And then we did announce a partnership to draw for the Gardent colon cancer based blood screening test and that will be underway later in the first quarter.
Sam Samad
Yeah, and from a guidance perspective, Tycho, you know, the partnerships with Grail and Gardens are reflected in our guide. You know, their modest contribution in terms of percentage of the total. The risk stratification test is, you know, again, very modest. It doesn’t launch until later in the year, so. But we are excited about that launch. Great operator. Next question.
operator
Thank you. Our next question comes from Andrew Brackman with William Blair. Your line is open, you may ask your question.
Andrew Brackmann
Yeah. Hi guys, good morning. Thanks for taking the Quest question here. So, Jim, maybe a big picture question for you sort of related to the opportunity for Quest and sort of monetizing the data that you generate. You know, you obviously generate quite a bit of it. So as you sort of think potentially about monetizing some of this longer term or maybe even partnering with some of these AI companies to further unlock that value. So sort of what are the things that you’re putting in place today to maybe start sort of going after that opportunity? Thanks.
James Davis
Yeah. You know, the data business has been a nice business for Quest. It’s growing, you know, double digits. It has been growing double digits for the last several years. You know, there’s multiple customers. When we think about who are the customers for that data, number one, the pharmaceutical industry, whether it’s targeting clinical trials, targeting patients with certain conditions, you know, type 2 diabetes, you name the condition, pharma turns to us to look for patient cohorts. We give patients when they’re getting a blood draw, the option to make their names available for clinical trials. And that has been very successful as well.
The payers tend to be a very good customer of this data. As an example, you know that people switch from Medicare Advantage plan to Medicare Advantage plan. If a patient switches from plan A to plan B, plan B will come to us and ask us for previous lab data, lab history of that patient so they can quickly understand what chronic conditions and other issues that that patient may be dealing with. And then I would say the public health agencies are also, you know, there’s certain tests that we, certain results that we have to provide public health agencies including the cdc.
But very often these public health agencies come to us and want to understand, you know, viral conditions, STD break outbreaks and things like that. And we highlight to them, I will say we’ve got partnerships with several different AI based companies that we are working with to better use the data to provide health insights and other population health insights to all the constituencies that I mentioned above.
Sam Samad
Great operator. Next question.
operator
Thank you. And this question comes from Elizabeth Anderson with Evercore isi. Your line is open, you may ask your question.
Elizabeth Anderson
Hey guys, good morning. Thanks for the question. I just had two quick modeling questions. One, and I apologize if I missed it, but can you just highlight the elevance and Stara, you know, re inclusion in their networks and sort of the impacts you think that that will put through in 2026 volumes. And then in response to Luke’s question, I understand that like core volumes are continuing to be strong. I just didn’t quite understand whether you were calling out that there was any weather impact from the cold weather and storms in January.
So I just want to make sure I have that down exactly. Thank you.
James Davis
Yeah. So again on elevance we mentioned in 2025 we got back in network in the states of Nevada, Colorado, we were partially in network in Georgia, but we were not in network with all of their plans. So back in Georgia and Virginia and you know, let’s just say it’s a three year ramp from our current share position with other health plans to get to that same level with elevance in those. So we’re now in year two so we expect continued share gains with that. Sentara, as you know, is a health system in Virginia and it has its own health plan and we’re the only one in their network on their health plan side.
So we’ll continue to get share gains in Virginia and the health plan actually goes even further south. So the health plan extends beyond just the Virginia border. So we’re excited about that as well.
Sam Samad
With regards to weather, Elizabeth. So what we said is the weather impact was significant in January, but it’s embedded in our guide for the year. So as we think about the year itself and the seasonality, we expect the seasonality to be similar to what we saw last year. Even with this weather impact that we saw in January, which was actually worse than January of last year, which in itself was pretty bad. But we had some pretty bad storms across the country in the second half of January. We do expect some recovery in the next two months or the next month and a half remaining in the quarter.
And you know, we’ve seen the underlying utilization has been very strong. So we’re encouraged by that operator. Next question.
operator
Thank you. Our next question comes from Peto Chickering with Deutsche Bank. Your line is open, you may ask your question.
Benjamin Shaver
Hey guys, you’ve got Benjamin Shaver on for peto. Thanks for taking the question. Just a quick1. On 26 guidance, how should we think about the price per rec versus requisition growth assumptions as it pertains to that. And also within the pricing assumption, how. Does the test per rec versus unit pricing play out? Thanks.
Sam Samad
Yeah, so we’re not going to provide the specific guidance around, you know, revenue per requisition. We usually don’t. We provide revenue assumptions in terms of the guide on a qualitative basis. I will tell you, I mean the impact that we talked about with regards to the, you know, high volume impact from Fresenius at a lower revenue per rec, still very profitable business. But you know, that will impact revenue per REC as a total in 2026. If you look at it more from an organic or sorry not organic, but just excluding those two businesses, Corewell and Fresenius, I think the rep for rec be consistent with what we’ve been seeing.
But you know, those two businesses, Corewell and Fresenius will impact and mostly Fresenius will impact REC for REC negatively as we saw in Q4. You know, in terms of the other factors within revenue per acquisition, I think the key thing that you should factor in is the fact that we continue to see tests per REC improve. We saw that across all of 2025. You know, and that improvement is driven by a number of factors, whether it’s the advanced diagnostics, more options for early screening, both cancer and other disease states, you know, guidelines evolving and physicians really gravitating towards more testing.
So all of those continue to play out and we’re still encouraged by definitely Based on what we saw in Q4 in terms of continued growth as per rec and what we expect to see in 2026. Operator, next question.
operator
Thank you. Our next question comes from Eugen park with Baird. Your line is open. You may ask your question. Hi, can you hear me? Yes, go ahead.
Yujin Park
Hi, thanks for taking my question. Can you quantify the impact from setting up the Synius in Corvall and maybe break out the project nova cost in 4q? And if you can elaborate more on how much setup, if there is any left to do, and if you can provide More color on 1Q26 on potential impact.
Sam Samad
Yeah, so I think I heard most of your question. If I didn’t catch all of it, please correct me. But you know, in terms of 4Q, I mean, without quantifying the exact impact, because we don’t want to get into quantifying every single quarter the impact of NOVA and also Fresenius Corwell, all I would say is there was a significant impact from the setup expenses of Fresenius and Corwell because we’re standing up these businesses. There’s integration costs, you know, there’s a lot of costs that you incur when you initially set up these new partnerships, both a COLAB partnership and in the case of Fresenius, a new partnership across dialysis, testing and then Nova.
We had also expenses in Q4. We had previously called out the fact that with the delayed signing of the contract with Epic, we had some expenses that got pushed out in Q4. And that’s in fact what played out in the quarter. You know, as you think about next year, in terms of specifically Nova, you know, we called out roughly 25 cent impact from Nova expenses in 20. Sorry, when I say next year, I mean 26. So when you think about 26, the impact is roughly $0.25. You know, the way I think about it is fairly even in terms of quarterly, you know, impact across the quarters.
Maybe slightly more in the first half than the second half, but not materially different. So, you know, I think you can model it fairly equally across the quarters.
James Davis
Okay, operator, thank you. And I’d like to thank everyone again for joining the call today. We certainly appreciate your continued support. Have a great day and stay healthy.
operator
Thank you for participating in Quest Diagnostics fourth quarter and year end 2025 conference call. A transcript of prepared remarks on this call will be posted later today on Quest diagnostics website at www.questdiagnostics.com. a replay of the call may be accessed online at www.questdiagnostics.com investor or by phone at 866-388-5361 for domestic callers or 203-369-0416 for international callers. Telephone replays will be available from approximately 10:30am Eastern Time on February 10, 2026, until midnight Eastern Time February 24, 2026. Goodbye.