Loss widens beyond expectations. Septerna Inc (NASDAQ: SEPN) reported a loss of $0.24 per share for Q4 2025, compared to the expected loss $0.22 per share. The biotechnology company posted a net loss of $10.7 million and an operating loss of $16.0 million for the quarter.
Revenue surges from minimal base. Revenue reached $24.1 million for the quarter, up 12.2% from Q3 2025’s $21.5 million. The sequential acceleration marks a dramatic shift from earlier in fiscal 2025, when Q2 and Q1 revenue totaled just $119,000 and $219,000, respectively. The company filed an 8-K and press release with the SEC detailing the results. Trading volume reached 556,530 shares, with the stock closing at $28.78, near the middle of its 52-week range of $4.66 to $32.63.
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