IPO details
Company intro
Dice Therapeutics is focused on developing oral therapeutics against well-validated targets in immunology. According to its filings, the company’s DELSCAPE platform works on discovering selective oral small molecules that can modulate protein-protein interactions with the same effectiveness as systemic biologics. Dice believes there is a significant unmet medical need for convenient oral therapies in chronic immunological diseases.
In July, Dice filed a Clinical Trial Application with the MHRA in the UK for its lead therapeutic candidate S011806, which is intended for the treatment of psoriasis. The company is planning on initiating a Phase I clinical trial in healthy volunteers and psoriasis patients. Dice is also developing oral therapeutic candidates for the treatment of inflammatory bowel disease and idiopathic pulmonary fibrosis.
Financials
Dice has thus far generated its revenue solely from research collaborations and activities and the company has not generated any revenue from product sales. Collaboration revenue totaled $0.9 million in 2020. The company recorded a net loss of $23.7 million for the year.
Market opportunity
Dice states in its filings that some of the drugs that are successful both clinically and commercially are biologics that modulate extracellular signalling by binding to cellular receptors or their ligands. Monoclonal antibodies (mAbs) form one such class of biologics and these represented a market of over $150 billion in 2020.
The company’s lead candidate S011806 is an orally-available small molecule antagonist of IL-17 being developed for the treatment of psoriasis. The global psoriasis drug market was estimated to be $20 billion in 2020, based on data from Evaluate Pharma. The total market opportunity for therapeutics targeting all IL-17 mAb-approved indications represented $26 billion in 2020.