An Effective Vaccine Target
“We desperately need new drugs for severe malaria. We’re hopeful that this might lead to a whole new class of anti-malarial drugs. It was a privilege to have the opportunity to share this work with colleagues at NIH, especially Drs. Patrick Duffy and Michal Fried who have helped advance our work at every stage,” said Dr. Kurtis.
(Source: Ocean Biomedical, Inc.)
Earlier, Dr. Jack Elias, the company’s other scientific co-founder and Dean Emeritus of Medicine and Biological Sciences at Brown University, had shared details of his team’s discoveries of the role that glycoprotein CHI3L1 has in regulating primary and metastatic lung cancer, glioblastoma multiforme, and broader oncogenic pathways. In his talk, Dr. Kurtis explained his unique Whole Proteome Differential Screening technique used to contrast the antibody repertoires of malaria-resistant children versus malaria-susceptible children. This technique has led to the discovery of three key targets that are being formulated into a highly effective malaria vaccine candidate being advanced by Dr. Kurtis and Ocean Biomedical.
Findings
Data generated by Dr. Kurtis’ lab has demonstrated that the family of small molecule candidates in development by his team are highly specific for PfGARP binding; are non-toxic in multiple in vitro and in vivo systems; have excellent pharmacokinetic properties; and rapidly clear parasitemia in animal models. The discovery has allowed the company to begin simultaneously pursuing the development of a novel malaria vaccine, and novel malaria therapeutics.
Fundamental Research Corp. initiates coverage of Ocean Biomedical (OCEA) with “Buy” recommendation
“This malaria vaccine discovery, along with the prior discovery of bispecific antibodies and immune checkpoint inhibitors that kill Glioblastoma cells and melanoma cells, will save thousands of lives and lead to long-term shareholder value growth. We look forward to bringing these malaria vaccine candidates to the people of Asia and Africa and to the possibility of preventing the leading cause of childhood deaths globally,” said Dr. Chirinjeev Kathuria, chairman and co-founder of Ocean Biomedical.